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A proposed model of MUC1 and EREG interaction in lung carcinogenesis. Cigarette smoke induces MUC1 expression that suppresses EREG in fibroblasts and transformed cells. Suppression of MUC1 facilitates EREG production from fibroblasts and transformed cells, which activates the EGFR/AKT pathway to compensate for MUC1 loss in epithelial cells, promoting lung carcinogenesis.
