Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cancer stem cells (CSCs) are Shh+ cells that secrete Shh full-length protein and induce autocrine (self-renewal and CSC stock maintenance) and paracrine activity (proliferation and survival signals, cell migration and epithelial-mesenchymal transition). All these signals are responsible for resistance to chemotherapy, radiotherapy and tumor proliferation in non-small cell lung cancer.
