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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Bone. 2018 Jan 4;109:225–231. doi: 10.1016/j.bone.2018.01.002

Figure 2. Effect of human Gly328 mutant receptor expression in bmp7sb1aub/sb1aub embryos.

Figure 2

A. mRNA misexpression in bmp7sb1aub/sb1aub mutant embryos. Phenotypes were scored at 24 hpf.

B. Phenotypes observed in bmp7sb1aub/sb1aub embryos injected with ACVR1 Glu328 mRNA and ACVR1 His206 mRNA. In parantheses, percent embryos with the phenotype. Classifications as in Figure 1 legend; C3 – lack of ventral tail fin and vein, truncated tail, and at least 14 somites present; C4 – preserved head tissue, less than 14 somites evident; C5 – disordered tissue development without discernible anatomical structures; lysis – dead embryos (C5 embryos typically lyse prior to 24 hpf).