Dangerous anaphylactic reaction to mustard

Food allergy is an important health problem and affects between 2% and 10% of the general population. In Europe it ranges from 0.1–3.2% for adults and 0.1–5.7% for children. According to the epidemiological data the prevalence of food allergy is increasing. Most cases of food allergy are associated with cows’ milk, hens’ eggs, peanuts, tree nuts, soy, wheat, shellfish and fish [1]. The European list of potentially dangerous allergens contains: cereals containing gluten, crustaceans, mollusks, eggs, fish, peanuts, tree nuts, soybeans, milk, celery, mustard, sesame, lupin and sulfur dioxide [2]. Food allergy can be IgE-mediated or non-IgE-mediated. IgE-mediated reactions have a rapid onset, affecting the skin, respiratory tract, and gastrointestinal tract, and in some cases can lead to systemic anaphylaxis, whereas non-IgE-mediated food allergy usually is delayed and affects mainly the skin and the gastrointestinal tract [3].

We report the case of a patient who experienced a severe anaphylactic reaction immediately after the ingestion of mustard.

A 38-year-old Caucasian woman ate sausage with mustard sauce. Within minutes, she was feeling dizzy and rapidly developed dyspneic symptoms with tightness of her chest, wheezing, and nausea, and subsequently she became unconscious. Following that, she developed widespread urticaria with pruritus. The examination in the hospital confirmed tachycardia of 135/min and blood pressure of 65/45 mm Hg. After she had been treated with adrenaline i.m., intravenous saline hydration, anti-histamine antihistamines and steroids gradual improvement was observed.

Having performed examinations after recovery from anaphylactic shock, except for stomach inflammation detected by upper gastrointestinal (UGI) endoscopy, ECG and spirometry were normal. No abnormal findings were noted on the chest X-ray and paranasal sinuses.

The complete blood count revealed hemoglobin, 16.8 g/dl; hematocrit, 49.1%; leucocytes, 11.69 × 10³ ml; neutrophils, 7.4 G/l; lymphocytes, 1.0 G/l; eosinophils, 0.03 G/l; monocytes 0.34 G/l and platelets, 367 000. She had no known food or drug allergies, but had seasonal allergic rhinitis in spring. Serum total IgE was 42.87 IU/ml and specific IgE determinations were remarkably positive to grass pollen (17.37 IU/l). Skin prick tests with common aeroallergens were positive to grass pollen. A strong skin prick test response was obtained with mustard allergens. Flow cytometry was normal.

The patient was instructed to avoid mustard sauce and seeds, including reading food labels, and was prescribed an epinephrine autoinjector.

There are two major types of mustard seeds: white (Sinapis alba L, or yellow mustard) and brown (Brassica juncea L, or oriental mustard). Sinapis alba, known as yellow mustard, is commonly consumed as a mustard sauce and added as a hidden condiment in many sauces and salad dressings in Europe [4–6]. However, very few cases of mustard seed-induced allergic reactions have been reported (Table I). Apart from celery, sesame, lupine, and shellfish, mustard is one of the most frequent spices causing IgE-mediated severe anaphylaxis. The mustard allergens are shown in Table II [4, 7].

Table I.

Some reported cases of allergic reactions induced by mustard

Case	Age/Gender	Symptoms and signs	History of food allergy and allergic disease	Positive reactions to skin tests and/or serum specific IgE	Reference
1	38/F	Anaphylactic shock	Allergy to mustard	Skin prick tests positive to mustard, coriander, and curry powder which contain mustard	[6]
2	47/F	Urticarial, facial angioedema nausea, vomiting, dyspnea, wheezing, chest tightness hoarseness	Seasonal rhinoconjunctivitis allergy to mustard	Positive skin tests with grass and olive pollen. Serum specific IgE against mustard strong positive (23.6 kU/l, class 4)	[4]
3	15/F	Urticaria, facial and throat swelling, chest tightness	Rhinoconjunctivitis, asthma	Serum specific IgE against mustard positive (18.5 ku/l]	[4]
4	48/F	Allergic contact dermatitis	Not recorded	Patch test with mustard seed – positive (erythema and bulla)	[13]
5	25/M	Allergic contact dermatitis	Lack of data	Patch test – positive with mustard oil at the concentrations 0.05%, 0.1%, 0.5%, 1% and 5%	[14]
6	38/F	Severe anaphylaxis after eating hidden mustard	Positive history of allergy to mustard	Skin prick tests positive to mustard, ige-specific antibody against mustard positive (56.3 ku/l)	[6]

Table II.

Characteristics of mustard allergens

Allergen	Properties	Cross-reactivity	References
Sin a 1 (2S albumin seed storage proteins)	14 kDa, – major allergen – diagnostic marker – has eight isoforms – stable after heating – resistant to gastric digestion		[10, 11]
Sin a 2 (11S globulin)	51 Da IgE-cross reactivity	Pru du 6, Cor a 9, Ara h 3, Jug r 4, Pis v 2, glycinins G1-G2, Ber e 2, Ana o 2, Ses i 6, Car i 4	[10–12]
Sin a 3 (nonspecific lipid transfer protein, LTP)	12 kDa – resistant to gastric digestion	Peach, melon, Artemisia vulgaris	[10, 12]
Sin a 4 (profilin)	13–14 kDa	Peach, melon	[12]

The present report shows that mustard can cause a life-threatening reaction. A variety of food reactions caused by mustard have been reported in the literature. Cuervo-Pardo et al. have described facial flushing, lower extremity urticaria, chest tightness and vomiting within 30 min of eating quinoa – a dish with mustard [7]. Some authors observed allergic contact dermatitis after exposure to mustard, while other authors observed the relationship between ingestion of mustard and atopic dermatitis severity [8, 9].

Approximately 50% of patients with mustard allergy are also sensitized to mugwort pollen and various foods of the Rosaceae family, nuts, and legumes [10].

Our patient has a history of pollen allergy and was diagnosed with IgE-mediated mustard-induced anaphylaxis. The time course of her allergic symptoms was correlated with the type I reaction according to Gell and Coombs. As well as high allergenic potency of mustard, it seems likely that there was cross-reactivity with grass pollen.

Allergy to plant food allergens is a significant health problem because of the high frequency of systemic allergic reactions. It is the most common cause of fatal and near-fatal food-induced anaphylaxis [11]. Proteins such as R-10 type proteins, lipid transfer proteins (LTPs), inhibitors of protease, chitinases, and α-amylases, peroxidases, profilins, vicilins, seed storage proteins, conglutins, glycinins, β-conglycinins, thiol-proteases and lectins are known cross-reactive allergens. Individuals allergic to tree, grass and weed pollens can develop symptoms ranging from the oral allergy syndrome (OAS) to anaphylactic shock after digestion of plants containing these proteins [12].

Nuts, mustard, soy, lupine and other allergenic plants could also have severe health consequences for consumers due to the hidden exposure [13, 14]. Therefore, it is important to label food with a legal obligation to declare certain food allergens. Patients should be educated on how to recognize the symptoms. They should also be trained in how to treat allergic reactions using an adrenaline autoinjector.

Conflict of interest

The authors declare no conflict of interest.