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. 2018 Mar 15;10(3):132. doi: 10.3390/v10030132

Figure 3.

Figure 3

Analysis of supernatants: 3T3 or 3T6 cells with no treatment (⍉) or following infection with 3 MOI UV-Inactivated HSV1716gfp (UV) or 3 MOI HSV1716gfp (V). Levels of Interferon-β were significantly increased in 3T3 cells infected with HSV1716gfp, while both 3T3 and 3T6 cell lines secreted high levels of HMGB1 protein following infection with replication competent virus. UV inactivated HSV1716gfp did not alter cytokine profiles compared to uninfected controls. Results are representative of three independent experiments. Horizontal bars represent means. Statistical significance was determined by one-way ANOVA (Tukey’s Multiple Comparisons Test). α = 0.05; * p < 0.05, ** p < 0.01. Abbreviations: ATP, adenosine triphosphate; HMGB1, high mobility group box 1; IFN, interferon’ MOI, multiplicity of infection.