Table 3.
Summary of clinical outcomes after subconjutival treatment of D-Dex, free-Dex and placebo (Positive control) gels. All results are displayed as mean ± standard deviation except for the opacity scores that are displayed as median (inter-quartile range). POD – post operative day; CCT – central corneal thickness; NV – neovascularization; IOP –intraocular pressure.
| Outcome measure | Group | Baseline | POD1 | POD3 | POD7 | POD14 |
|---|---|---|---|---|---|---|
| CCT (μm) | D-Dex | 122.08 ± 28.17 | 288.58 ± 72.27 | 307.46 ± 128.98 | 165.54 ± 68.64 | 174.9 ± 115.15 |
| Free-Dex | 142.86 ± 8.68 | 304.95 ± 87.23 | 357.71 ± 115.58 | 229.57 ± 91.54 | 226.57 ± 63.67 | |
| Positive controls | 132.8 ± 20.09 | 291.9 ± 38.67 | 370.3 ± 92.10 | 250.6 ± 79.37 | 286.83 ± 156.57 | |
| Opacity score | D-Dex | 0(0) | 2(3) | 2.5(2) | 1(1) | 0(0) |
| Free-Dex | 0(0) | 3(3) | 3.5(1) | 1(1) | 1(2) | |
| Positive controls | 0(0) | 3(3) | 4(1) | 2.5(1) | 2.5(3) | |
| Estimated area of NV (mm2) | D-Dex | 0±0 | 0 ± | 2.5 ± 1.57 | 2.21 ± 2.53 | 3.43 ± 4.2 |
| Free-Dex | 0±0 | 0±0 | 3.32 ± 1.65 | 3.8 ± 2.89 | 43.32 ± 5.46 | |
| Positive controls | 0±0 | 0±0 | 4.03 ± 1.02 | 7.74 ± 3.02 | 8.29 ± 5.4 | |
| IOP (mmHg) | D-Dex | 10.29 ± 1.73 | 10.63 ± 2.02 | 10.00 ± 0.98 | 11.33 ± 3.03 | 10.90±2.08 |
| Free-Dex | 11.36 ± 1.84 | 10.73 ± 2.07 | 12.14 ± 2.93 | 14.45 ± 2.32 | 19.38±3.89 | |
| Positive controls | 11.23 ± 1.54 | 11.59 ± 2.97 | 11.91 ± 6.02 | 16.77 ± 5.31 | 17.50±6.32 |