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Maternal folic acid supplementation increased global DNA methylation level and DNMT activity in offspring brain. Dams were fed as described in Figure 1. (A) Global DNA methylation level (5-mC level) in brain tissue of offspring; (B) DNMT activity in brain tissue of offspring. * p < 0.05 compared with DD group. # p < 0.05 compared with ND group. & p < 0.05 compared with FD-S group. Data are expressed as mean ± SD for n = 10 pups/group (same pups as Figure 2).
