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. 2018 Jan 18;37(13):1759–1774. doi: 10.1038/s41388-017-0118-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. If you remix, transform, or build upon this article or a part thereof, you must distribute your contributions under the same license as the original. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/.

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Fig. 1 — NDRG2 is a differentiation-specific marker in CRCs. a Immunohistochemistry staining of NDRG2 in human adjacent normal and cancerous colon tissues from CRC patients. b, c NDRG2 expression in human tissues at different stage b or differentiation status c. Student’s t-test was applied for statistical analyses. d, e Kaplan–Meier plots indicate the clinical outcomes for different CRC differentiation status d or NDRG2 expression patterns e by immunohistochemistry staining in CRCs. f-i Silico analysis of 383 primary CRC tissues of the multidimensional data set from The Cancer Genome Atlas (TCGA) cbioportal data set. f Clinical outcomes for NDRG2 expression pattern were evaluated. g The correlation between the TCGA expression and methylation data for NDRG2 in CRC adenocarcinoma. h, i Clinical outcomes for the gene expression patterns given at the top of each panel. e, f,h, i For NDRG2, CDKN1A and CDKN1B, high expression indicates expression above the mean, calculated across all samples. Conversely, low expression indicates expression below the mean. a-i n indicates the number of patient samples evaluated in each analysis. P-values were calculated using the Mantel–Cox log-rank test. **P < 0.01. ***P<0.001