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Natural tropism of adenoviral platforms.
| Subgroup | Serotype | Attachment Receptors | Natural Tropism |
|---|---|---|---|
| A | 12 | CAR | Gastrointestinal |
| B1 | 35 | CD46 | Respiratory |
| B2 | 3 | DSG-2 | Renal |
| B3 | 11 | CD46 and DSG-2 | Renal |
| C | 2 and 5 | CAR | Respiratory |
| D | 19 | CAR and sialic acid | Ocular |
| E | 4 | CAR | Respiratory and Ocular |
| F | 40 and 41 | CAR | Gastrointestinal |
| G | 52 | unknown | Gastrointestinal |
CAR: coxsackie-adenovirus receptor; DSG-2: desmoglein-2.
