Table 1.
(S)-ketoprofen parameters. Mean ± SEM, n = 6. * p < 0.05.
| Pharmacokinetics | (S)-Ketoprofen | (S)-Ketoprofen + Caffeine |
|---|---|---|
| Cmax (μg/mL) | 2.73 ± 0.27 | 5.19 ± 0.59 * |
| Tmax (h) | 0.50 ± 0.00 | 0.50 ± 0.00 |
| AUC0-24 (μg·h/mL) | 34.49 ± 6.11 | 63.03 ± 7.66 * |
| AUC0-∞ (μg·h/mL) | 71.17 ± 18.58 | 112.17 ± 24.78 * |
| λz (h−1) | 0.0389 ± 0.01 | 0.0404 ± 0.01 |
| t½ (h) | 26.94 ± 9.22 | 18.45 ± 3.45 |
| MRT (h) | 38.38 ± 12.72 | 26.66 ± 5.71 |
| Pharmacodynamics | ||
| Emax (%) | 47.93 ± 5.07 | 81.09 ± 3.74 * |
| Tmax (h) | 0.83 ± 0.25 | 2.0 ± 0.52 * |
| AUC0-4 (%h) | 141.35 ± 18.09 | 287.80 ± 14.02 * |
| Sigmoidal Emax model | ||
| Emax (%h) | 252.21 ± 27.27 | 1486.97 ± 463.58 * |
| EC50 (μg·h/mL) | 5.49 ± 1.58 | 43.67 ± 21.45 * |
| Response factor (γ) | 1.64 ± 0.16 | 1.25 ± 0.10 |
Mean residence time (MRT).