For more information on this topic, CDC recommends the following link: https://www.cdc.gov/drugoverdose/.
Footnotes
Deaths per 100,000 population age-adjusted to the 2000 U.S. standard population.
As underlying cause of death, drug overdose (including accidental, intentional, assault, and undetermined intent) was identified with the International Classification of Diseases, Tenth Revision (ICD-10) codes X40-X44, X60-X64, X85, Y10-Y14. The number of drug overdose deaths was 52,404 in 2015 and 63,632 in 2016.