. 2018 Jan 27;21(2):183–202. doi: 10.1007/s10456-018-9600-2

Table 1.

MicroRNAs involved in regulating HIFs and HIF regulatory gene levels in ECs

miRNA	Cell type	Impact of hypoxia on miRNA expression	miRNA target (s) (direct or indirect*)	Investigated processes	References
miR-18a	Choroidal endothelial cells	Upregulated	HIF1A	Proliferation migration	[116]
miR-107	Endothelial progenitor cells—EPCs	Upregulated	ARNT	Differentiation	[121]
miR-135b	HUVECs	Upregulated	HIF1AN	Angiogenesis	[124]
miR-135b	HUVECs	Upregulated	HIF1A*	Angiogenesis	[124]
miR-155	Mouse skin endothelial SENDs cells and HUVECs	Upregulated	HIF1A	Angiogenesis hypoxia	[108]
miR-199a	Endometrial stromal cells; endothelial EA.hy926 cells	Not shown	HIF1A	Angiogenesis	[123]
miR-200b	HMVECs	Downregulated upregulated	ETS1	Angiogenesis hypoxia	[135, 136]
miR-200b	HUVECs	Downregulated upregulated	KLF2	Angiogenesis hypoxia	[135, 136]
miR-210	HUVECs	Upregulated	EFNA3	Angiogenesis hypoxia	[131, 132, 150]
miR-210	HUVECs	Upregulated	HIF3A	Angiogenesis hypoxia	[131, 132, 150]
miR-424	HUVECs, hMVECs, hBOECs and hMBECs	Upregulated	CUL2	Angiogenesis	[137]
miR-424	HUVECs, hMVECs, hBOECs and hMBECs	Upregulated	HIF1A*	Angiogenesis	[137]
miR-429	HUVECs	Upregulated	HIF1A	Hypoxia	[12, 109]
miR-429	HUVECs	Upregulated	HIF3A	Hypoxia	[12, 109]
miR-433	HUVECs	Downregulated	HIF1A	Proliferation and migration	[138]

miRNAs proven to directly bind HIF mRNAs are in bold, and indirect effects are marked with “*”

ARNT aryl hydrocarbon receptor nuclear translocator, CUL2 cullin-2, EFNA3 ephrin A3, EGLN1 prolyl hydroxylase domain-containing protein 2 (PHD2), ETS1 ETS Proto-Oncogene 1, Transcription Factor, HIF1A hypoxia-inducible factor 1-alpha, HIF1AN hypoxia-inducible factor 1-alpha inhibitor, HIF3A hypoxia-inducible factor 3 alpha, KLF2 Kruppel-like factor 2