Table 5. The number of TILs at the invasive margin (/field).

	Exploratory Group		Validation Group
	At random	Hot spot	At random	Hot spot
CD4 (Median [range])
tTILs	4.2 (0-36.6)	18.4 (1.2-60.4)	2.2 (0-13.8)	18.8 (4-51.0)
sTILs	4.2 (0-36.6)	18.4 (1.2-60.4)	2.2 (0-13.8)	18.8 (4-51.0)
iTILs	0 (0-0.4)	0 (0-0.2)	0 (0-2.2)	0 (0-4.4)
CD8 (Median [range])
tTILs	7.6 (0.4-37.8)	39 (9.4-114.2)	12.5 (0.2-34.2)	32.6 (7.0-79.6)
sTILs	5.0 (0-29.0)	37.4 (3.8-114.2)	11.6 (0.2-29.8)	32.6 (7.0-79.6)
iTILs	1.6 (0-16.4)	0 (0-16.8)	0.2 (0-12.8)	0 (0-4.0)

TILs: Tumor-infiltrating lymphocytes, tTILs: total TILs (sTILs+iTILs), sTILs: TILs in tumor stroma, iTILs: TILs intra tumor cells.