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. 2018 Feb 26;9(22):16248–16262. doi: 10.18632/oncotarget.24575

Figure 1. SLAM members, cellular and molecular characteristics.

Figure 1

HSCs: Hematopoietic Stem Cells; DCs: Dendritic Cells; NK: Natural Killer; PKCƟ: Protein Kinase C Ɵ; BCL10: B-Cell Lymphoma 10; NF-ƙB: Nuclear Factor-ƙB; SHP-1/2: SH2 domain-containing Phosphatase 1/2; SHIP1: SH2-containing Inositol 5'-polyphosphatase 1; SHC: Src Homology 2 domain Containing; Btk: Bruton’s tyrosine kinase; Lck: Lymphocyte-specific protein tyrosine kinase; Dok1/2: Docking protein 1/2; Ras-GAP: Ras GTPase-activating proteins; LAT: Linker for activation of T cells; Grb2: Growth factor receptor bound protein 2; AP-2: Adaptor Protein complex-2; ERK: Extracellular signal-Regulated Kinases; PI3K: PhosphoInositide 3-Kinase; mTOR: mammalian Target of Rapamycin; RB: Rétinoblastoma; PLCγ: PhosphoLipase Cγ; Cbl: Casitas B-lineage Lymphoma; CSK: COOH-terminal Src kinase; 3BP2: Abl-SH3 Binding Protein 2. Localisation of ITSM (TxYxxI/V) were determined on Ensembl. [1, 2, 11, 21, 84, 95].