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. 2018 Feb 26;9(22):16248–16262. doi: 10.18632/oncotarget.24575

Figure 2. Mechanisms of Elotuzumab against myeloma cells.

Figure 2

SLAMF7 and CD16 on NK cells can bound to Elotuzumab. The binding to SLAMF7 induces NK cell activation and enhances cytolysis function against myeloma cells. While the binding to CD16 receptor can induce the release of Perforin/Granzyme by NK cells and subsequently enhance ADCC against myeloma cells overexpressing SLAMF7. Moreover, CD16 (NK cells), Elotuzumab and SLAMF7 (Myeloma cells) can enhance NK cell cytotoxicity against myeloma cells independent of ADCC. Furthermore, Elotuzumab-SLAMF7 interaction can inhibit the adhesion between myeloma cells and BMSC.