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. 2017 Dec 1;32(4):874–881. doi: 10.1038/leu.2017.313

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Copyright © 2018 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Proposed algorithm for application of the Compass tool results. Cases in which the Compass shows a main pointer towards B, T, or Myeloid (with >10% of events) and that have no mixed events or <10% mixed events can be stained immediately with the classification panel of the main pointer. This accounts for 84% of cases (n=650); of these only two (0,3%) were classified as MPAL after review. All other cases (16% of total; n=133) need manual selection of the right classification panel; 36% of these were diagnosed as MPAL.