Table 1. Characteristics of patients used for validation of the database-guided analysis.

	Parameter	Validation cohort	Databasea	Total
WHO diagnosis (n)	T-ALL	46	145	191
	BCP-ALL	158	377	535
	AML	523b	134	657
	MPAL	55	0	55
	AUL	1	0	1
Gender (n)	F	326	265	591
	M	455	389	844
	Unknown	2	2	4
Age (years)	Median	39	6	10
	Range	0-95	0-84	0-95
WBC (109/l)	Median	19.8	14	16
	Range	0.5-754	1–1000	0.5–1000
Disease phase (n)	Diagnosis	767	634	1401
	Relapse	12	21	33
	Unknown	4	1	5
Sample type (n)	Bone marrow	695	586	1280
	Peripheral blood	87	68	155
	Otherc	1	2	3

Abbreviations: AML, acute myeloid leukemia; AUL, acute undifferentiated leukemia; BCP-ALL, B-cell precursor acute lymphoblastic leukemia; MPAL, mixed phenotype acute leukemia; T-ALL, T-cell acute lymphoblastic leukemia.

^aadditional details can be found in Supplementary Table 1.

^bIncluding two blastic plasmacytoid dendritic cell neoplasms

^cone cerebrospinal fluid sample in the validation cohort; two pleural efussion samples in the database cohort.