Table 1.

Summary of Csk KO, CD148 KO, and DKO mouse phenotypes

Phenotype	Genotype
	Csk KO	CD148 KO	DKO
Bleeding	↑	—	↑↑
Thrombosis
In vivo
Laser injury	↓	↓	↓↓
FeCl3 injury	↓↓	↓	↓
Ex vivo
T-TAS
Collagen	↓	↓	↓↓
Collagen, tissue factor	—	—	—
Flow chamber
Collagen	↓	↓	↓↓
vWF-BP, laminin, rhodocytin	↓	↓	↓
Platelet count	↓	—	—
Platelet receptors
Expression
GPVI-FcRγ-chain	↓↓	↓	↓↓↓
CLEC-2	↓	—	↓↓
G6b-B	↑↑	—	↑↑
Phosphorylation
G6b-B	↑↑	—	↑↑↑
SFK activity	↑	↓	↑↑

↑, upregulated; ↓, downregulated; —, normal.