Figure 12.

Excitatory responses are strongly attenuated by NK1 antagonist. A, B, Representative ST maps showing the inhibitory effects of RP 67580 (1 μM), in the presence of nitric oxide synthase inhibitor L-NNA (100 μM) and purinergic P2Y1 receptor antagonist (MRS 2500; 1 μM) on Ca²⁺ transients in response to nerve stimulation (EFS at 10 Hz 5 s; indicated by the red line and dotted white box in ST maps). C–F, Summary data showing the effects of a combination of L-NNA, MRS 2500, and RP 67580 on Ca²⁺ transient frequency (C), amplitude (D), duration (E), and spatial spread (F) in ICC-DMP during the control period, during the final 3 s of EFS, and during the post-EFS period (5 s), n = 4, c = 13; ns = p > 0.05, **p < 0.01.