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. 2018 Apr 6;5(2):ENEURO.0080-18.2018. doi: 10.1523/ENEURO.0080-18.2018

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Copyright © 2018 Baker et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 8. — Neurokinin receptor (NK1) agonists activate Ca²⁺ transients. A, Representative ST maps showing the excitatory effects of SP (1 μM; in the presence of TTX) on Ca²⁺ transients in ICC-DMP. B–E, Summary graphs showing the effects of SP (in the presence of TTX) on the frequency (B), amplitude (C), duration (D), and spatial spread (E) of Ca²⁺ transients in ICC-DMP. F, Representative ST maps showing the excitatory effects of the NK1 receptor agonist GR 73632 (1 μM; in the presence of TTX) on Ca²⁺ transients in ICC-DMP (n = 4, c = 10). G–J, Summary graphs quantifying the effect of GR 73632 on the frequency (G), amplitude (H), duration (I), and spatial spread (J) of basal Ca²⁺ transient activity in ICC-DMP (n = 4, c = 9); ns = p > 0.05, *p < 0.05, **p < 0.01, ****p < 0.0001.