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. Author manuscript; available in PMC: 2018 Apr 9.
Published in final edited form as: Virology. 2017 Oct 16;513:91–97. doi: 10.1016/j.virol.2017.08.030

Fig. 4. Schematic diagram of mechanisms involved in BBI-mediated HIV entry inhibition in macrophage.

Fig. 4

IFN-β released from BBI-treated macrophages binds to type I IFN receptors on the cell membrane, and activates intracellular JAK/STAT pathway, leading to the induction of CC chemokines and reduction of CCR5, which contributes to the BBI-mediated inhibition of HIV entry into macrophages.