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. 2018 Mar 27;9(23):16297–16310. doi: 10.18632/oncotarget.24631

Table 4. Relation of ALK5-FL, ALK5-ICD, pSMAD2/3 and PAI-1 protein levels to categorized clinicopathological parameters in ccRCC VHL-High.

Parameter	ALK5-FL			ALK5-ICD			pSMAD2/3			PAI-1
Parameter	n^a	Mean Rank	P-Value^b	n^a	Mean Rank	P-Value^b	n^a	Mean Rank	P-Value^b	n^a	Mean Rank	P-Value^b
Grade
I (I+II)	34	35.78		34	32.24		34	33.47		34	30.13
			0.911			0.206			0.416			0.032
II (III+IV)	36	35.24		36	38.49		36	37.42		36	40.57
TNM Stage
Early Stage (I+II)	37	34.12		37	30.11		37	35.20		37	29.46
			0.548			0.019			0.897			0.009
Advanced Stage (III+IV)	33	37.05		33	41.55		33	35.83		33	42.27
Tumor size (mm)
<70	29	38.47		29	37.62		29	36.03		29	36
			0.305			0.463			0.853			0.863
>70	41	33.40		41	34		41	35.12		41	35.15

^a Number of patients.

^b Groups were compared using Mann-Whitney U test (significant at P<0.05).