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. Author manuscript; available in PMC: 2018 Apr 11.
Published in final edited form as: Neuroscience. 2015 Jan 28;290:115–125. doi: 10.1016/j.neuroscience.2015.01.034

Fig. 1.

Fig. 1

Nicotine increased nociceptive responses to mechanical stimulation of trigeminal neurons. Nicotine or PBS was delivered via an implanted osmotic for 14 days. (A) Bar graph depicting average nocifensive responses to 60 grams of force in the eyebrow region in both the PBS control and nicotine groups prior to implantation and 14 days later (n=6). (B) Bar graph depicting average nocifensive responses to 60 grams of force in the eyebrow region in both the PBS control and nicotine groups prior to implantation and 14 days post-surgery (n=6). *P ≤ 0.05 when compared to basal values, #P ≤ 0.01 when compared to control values.