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. 2018 Jan 9;159(4):739–748. doi: 10.1097/j.pain.0000000000001137

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Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 1. — Nocifensive responses in rats evoked by intra-articular injection of MSU crystals. (A) Timeline of behavioral experiments after injection of amorphous or needle MSU crystals or PBS into the right knee joint; arrows signal the time at which experimental measures were performed. (B) Images of the knee joints exposed by removal of the skin, in the MSU-injected (left panel) and the contralateral, non-injected (right panel) hind limb. (C-F) Change in knee-joint diameter (C), % weight-bearing asymmetry (D), von Frey mechanical threshold (E) and cold (acetone) sensitivity (F), measured 3, 5, and 8 hours after ipsilateral injection of: amorphous MSU (black, n = 10); needle MSU (blue, n = 7); PBS (green, n = 12), and in untreated joint (cyan, n = 12). Paired t test ***P < 0.001, **P < 0.01 with baseline values. MSU, monosodium urate; PBS, phosphate buffered saline.