Fig. 4.

C. albicans vps4 mutants are less invasive than wild-type controls. Histopathologic examination was performed using hematoxylin and eosin (H & E) and Gomori-methanamine silver (GMS) staining on selected kidneys from the murine disseminated candidiasis experiments. In the wild-type strain, (a, b) multiple fungal microabscesses have formed in the renal papilla and calices, with minimal involvement of the cortical area. In contrast, there are no fungal microabscesses seen in the vps4Δ null mutant in any part of the kidneys. Representative sections are shown (c, d). Panels A and C are stained using H&E, panels B and D are strained with GMS