Table 3.
Vaccine effectiveness (VE) against incident zoster by sex, vaccination cohort, history of zoster and time since vaccination.
| Factor | Vaccine effectiveness against incident zoster |
||||
|---|---|---|---|---|---|
| Level | Vaccinated cases/Pyearsa (rate)b | Unvaccinated cases/Pyearsa (rate)b | VE (95% CI)c | pinteractiond | |
| By vaccination cohort | Routine | 230/77,319 (2.97) | 4521/540,007 (8.37) | 62% (56%, 67%) | |
| Catch-up | 205/60,649 (3.38) | 3485/369,467 (9.43) | 64% (58%, 69%) | 0.58e | |
| By sex | Male | 161/64,925 (2.48) | 3271/424,381 (7.71) | 66% (60%, 71%) | |
| Female | 274/73,044 (3.75) | 4735/485,093 (9.76) | 60% (54%, 64%) | 0.08e | |
| By history of zoster | No history | 365/123,185 (2.96) | 7145/821,116 (8.70) | 64% (60%, 68%) | |
| History | 70/14,784 (4.73) | 861/88,358 (9.74) | 47% (31%, 58%) | 0.009e | |
| Time since vaccination | <=1 year | 197/75,707 (2.60) | 69% (65%, 74%) | ||
| 1–2 years | 178/47,954 (3.71) | 8006/909,474 (8.80) | 54% (47%, 61%) | ||
| 2–3 years | 60/14,307 (4.19) | 45% (29%, 57%) | <0.001f | ||
| Time since vaccination by cohort | Routine | ||||
| <=1 year | 95/41,602 (2.28) | 71% (65%, 76%) | |||
| 1–2 years | 103/26,640 (3.87) | 4521/540,007 (8.37) | 49% (38%, 58%) | ||
| 2–3 years | 32/9077 (3.53) | 52% (32%, 67%) | 0.0002f | ||
| Catch-up | |||||
| <=1 year | 102/34,105 (3.00) | 69% (62%, 74%) | |||
| 1–2 years | 75/21,313 (3.52) | 3485/369,467 (9.43) | 61% (50%, 69%) | ||
| 2–3 years | 28/5230 (5.35) | 38% (9%, 58%) | 0.01f | ||
a
Excludes person-time in the 42 days after vaccination.
b
Rate/1000 person-years.
c
Adjusted for age in years, month and year of study.
d
p value for interaction.
e
Calculated using Wald test for interaction.
f
Calculated using likelihood ratio test.