Table 2.
Biochemical parameters and medications of hemoglobin variability.
| Patient characteristics | HA (n: 39) | High (n: 13) | Target (n: 42) | Low (n: 37) | LAH (n: 16) | LAL (n: 22) | p |
|---|---|---|---|---|---|---|---|
| Hemoglobin (g/dl) | 10.7 ± 0.7 | 12.7 ± 0.8 | 11.1 ± 0.4 | 9.9 ± 0.8 | 12.2 ± 1.0 | 9.6 ± 0.6 | 0.001 |
| Hb-var (g/dl)∗ | 1 (0.4) | 0.7 (0.3) | 0.8 (0.3) | 0.8 (0.2) | 1 (0.1) | 0.9 (0.2) | 0.001 |
| Maximum Hb-var (g/dl)∗ | 4 (1.5) | 2.4 (1.2) | 2.5 (0.8) | 2.6 (1.3) | 3.9 (1.1) | 3.6 (0.8) | 0.001 |
| Coefficient of Hb-var∗ | 9.3 (4.1) | 5.9 (2.8) | 7.3 (2.7) | 7.8 (2.8) | 8.4 (1.5) | 10.1 (2.9) | 0.001 |
| MCV (fl) | 90.1 ± 3.9 | 89.1 ± 4.2 | 91.2 ± 4.6 | 91.5 ± 5.2 | 86.8 ± 6.8 | 88.1 ± 7.0 | 0.017 |
| RDW (%)∗ | 16.5 (2.4) | 16.3 (2.2) | 15.8 (1.5) | 16.0 (1.2) | 16.9 (1.6) | 16.1 (1.6) | 0.085 |
| Leukocyte (×103/µl) | 7.0 ± 1.7 | 6.4 ± 1.3 | 6.7 ± 1.6 | 5.9 ± 1.7 | 7.3 ± 2.1 | 6.9 ± 1.6 | 0.05 |
| Calcium (mg/dl) | 9.4 ± 0.6 | 9.0 ± 0.6 | 9.2 ± 0.6 | 9.2 ± 0.8 | 9.2 ± 0.9 | 8.8 ± 0.6 | 0.135 |
| Phosphate (mg/dl) | 5.7 ± 1.5 | 5.3 ± 0.4 | 5.0 ± 1.2 | 5.1 ± 1.4 | 5.0 ± 1.1 | 5.1 ± 1.0 | 0.239 |
| Albumin (g/dl) | 4.0 ± 0.3 | 4.3 ± 0.3 | 4.1 ± 0.3 | 4.1 ± 0.3 | 4.2 ± 0.6 | 4.1 ± 0.4 | 0.144 |
| CRP (mg/l)∗ | 9.7 (13) | 4.7 (6) | 9.7 (15) | 7.6 (14) | 11.2 (10) | 7.5 (22) | 0.744 |
| Transferrin saturation%∗ | 29.7 (12) | 35.5 (14) | 32.3 (13) | 29.2 (23) | 28.5 (17) | 29.0 (17) | 0.907 |
| Ferritin (µg/l)∗ | 275 (400) | 124 (86) | 310 (222) | 382 (298) | 196 (248) | 462 (400) | 0.001 |
| PTH (pg/ml)∗ | 445.7 (728) | 303.7 (400) | 281.3 (508) | 491.2 (1078) | 214.4 (515) | 299.7 (401) | 0.118 |
| URR% | 66.2 ± 5.3 | 65.4 ± 4.6 | 66.1 ± 6.5 | 67.7 ± 6.7 | 64.4 ± 6.3 | 65.5 ± 8.5 | 0.600 |
| MIS∗ | 7 (4) | 5 (5) | 7 (4) | 6 (3.5) | 7 (2.8) | 7.5 (4) | 0.471 |
| ESA total dose per body weight (U/kg)∗ | 3.3 (3.4) | 0.3 (0.6) | 3.0 (2.4) | 4.9 (1.4) | 0.5 (1.6) | 5.1 (2.1) | 0.001 |
| Iron per body weight (mg/kg)∗ | 15.7 (25) | 14.7 (27) | 13.4 (16) | 16.5 (19) | 18.2 (19) | 11.7 (20) | 0.167 |
| Months of hb < 11 g/dl | 6.5 ± 2.3 | 0.5 ± 0.6 | 4.3 ± 2.0 | 9.9 ± 1.7 | 2.2 ± 2.4 | 10.4 ± 1.2 | 0.001 |
| 10 year survival∗ | 21 (77) | 21 (56) | 21 (77) | 53 (76) | 21 (69) | 53 (77) | 0.851 |
HA: high-amplitude fluctuation; LAH: low-amplitude fluctuation with high hemoglobin; LAL: low-amplitude fluctuation with low hemoglobin; Hb-var (hemoglobin variability); MCV: mean corpuscular volume: RDW: red blood cell distribution width; CRP: C-reactive protein; PTH: parathyroid hormone; URR: urea reduction ratio; MIS: malnutrition-inflammation score; ESA: erythropoiesis-stimulating agents. ∗Median (Interquartile range); other results are given as mean ± standard deviation.