Skip to main content
. 2018 Apr 14;391(10129):1483–1492. doi: 10.1016/S0140-6736(18)30021-7

Figure 1.

Figure 1

The location of mutations in the NaV1.4 channel

The location of mutations in the NaV1.4 channel Transmembrane helices S1–S6 are labelled in domains I–IV. The S4 helices contain positively charged arginine residues (+). The S1–S4 helices form voltage-sensing domains. The S5–S6 helices are pore-forming. The variants in the SIDS cohort (from N-terminus to C-terminus) are: Ser682Trp, Gly859Arg, Val1442Met, Arg1463Ser, Met1493Val, and Glu1520Lys. The variants in the control cohort (from N-terminus to C-terminus) are: Arg179Gln, Arg190Trp, Leu227Phe, Asp334Asn, Gly863Arg, Ala870Thr, Met897Lys, and Val1590Ile. SIDS=sudden infant death syndrome.