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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Steroids. 2017 Oct 31;133:87–92. doi: 10.1016/j.steroids.2017.10.012

Figure 1. Schematic structure of paxillin with highlights of nuclear function related domains.

Figure 1

Paxillin contains five LD domains on the N-terminal half and four LIM domains on the C-terminal half of the protein. The shown N-terminal domains are critical for FAK binding and nuclear translocation, with highlights of critical serine/tyrosine phosphorylation sites as well as the NES sequence within LD4 domain. The LIM domains on the C terminal half are related to paxillin’s binding and transactivating of AR and GR.