Skip to main content
. Author manuscript; available in PMC: 2018 Apr 19.
Published in final edited form as: Biochemistry. 2017 Nov 10;56(47):6200–6210. doi: 10.1021/acs.biochem.7b00741

Figure 5. Zta binding to DNA 8-mers with either 5mC or 5mCG.

Figure 5

Zta binding to DNA 8-mers with either 5mC or 5mCG. Z-scores for Zta binding to 8-mers with one cytosine in a CG dinucleotide with 5mC in one strand (x-axis), or those in which both cytosines in the CG dinucleotide are methylated (y-axis) are shown as black spots. 8-mers with the CG dinucleotide at the beginning of the 8-mer ( C−4G−3DDDDD, where D= A, G, or T) are shown in blue and those with the CG dinucleotide at C2G3 ( DDDDC2G3D) are shown in magenta. As a control, cytosine containing 8-mers for paired experiments in which the double-stranding reaction contained unmodified cytosines are depicted in gray. A sequence logo generated using the top 20 8-mers bound when both cytosines in the CG dinucleotide are methylated is shown.