Figure 5.
Preservation of ERG by MANF. The right eyes of rd 10 mice were treated with 2 µg (in 1 µl of PBS) of MANF by intravitreal injection at PD18. The left eyes were treated with PBS. ERGs were recorded from both eyes simultaneously 10 d later at PD28. Scotopic b-waves evoked by white light flashes of −0.4 log cd-s/m2 were reliably recorded but the a-waves were undetectable (A). Significantly higher b-wave amplitudes were recorded from MANF-treated eyes, with an average amplitude of 115 ± 16.5 μV (n = 5), as compared with PBS-treated eyes whose average amplitude is 82.4 ± 10.7 μV (n = 5; B, double asterisks indicate p = 0.0017, Student’s t test).