Based on qRT-PCR, Oc90 is expressed mostly before birth in the utricle and saccule (A), ampulla (B), canal (C) and cochlea (D). *** denote p<0.001 when compared with E17.5 (n=6 for each age group). U+S, utricle and saccule. Based on fluorescent immunostaining, Oc90 protein is abundant in the developing (E & F), mature (G) and aging (H) otoconia (utricle shown). O, otoconia; SE, sensory epithelia.