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. 2018 Apr 6;9(26):18041–18052. doi: 10.18632/oncotarget.24710

Figure 6. Quantification of cytotoxicity and synergy of OAd-hamIFN combination therapies based on the colony formation assay.

Figure 6

Combination of OAd-hamIFN with 5-FU, radiation, and chemoradiation reduced number of colonies formed in hamster pancreatic cancer cell lines. The strong synergism (CI < 1) was identified in groups treated with OAd-hamIFN in combination with chemotherapy, radiation, and chemoradiation. In both cell lines, combinations of OAd-hamIFN and chemoradiation in higher doses resulted in the strongest killing effect and synergistic interaction. The Chou Talalay method was used to determine the combination index (CI). Synergistic effect (CI < 1); additive effect (CI = 10); antagonistic effect (CI > 1). The numbers on the top of the histogram bars represent the percent of colonies formed after each treatment.