Table 2. Genotype Frequencies and Scoring for Each Polymorphism.
Polymorphism | Genotypes | n | Frequency |
DA-related composite score |
|
---|---|---|---|---|---|
Additive | Dominant | ||||
DAT1 VNTR | 9/9 | 16 | 0.17 | High | High |
9/10 | 36 | 0.38 | Intermediate | High | |
10/10 | 42 | 0.45 | Low | Low | |
COMT rs4680 | Met/met | 25 | 0.27 | High | High |
Met/val | 41 | 0.44 | Intermediate | High | |
Val/val | 28 | 0.30 | Low | Low | |
DRD2 rs1076560 | T/T | 1 | 0.01 | High | High |
T/G | 27 | 0.29 | Intermediate | High | |
G/G | 66 | 0.70 | Low | Low | |
DRD4 VNTR | Long/long | 3 | 0.03 | High | High |
Long/short | 29 | 0.31 | Intermediate | High | |
Short/short | 61 | 0.65 | Low | Low |
For the DA-related genetic composite measure, two scoring models were evaluated. For the additive model, “high” genotypes (two alleles associated with higher DA tone) were scored as 2, “intermediate” genotypes as 1, and “low” genotypes as 0, and the total possible score ranged from 0 (no higher DA alleles) to 8 (all higher DA alleles). For the dominant model, homozygous “high” genotypes and heterozygous “intermediate” genotypes were each scored as 1 and “low” genotypes as 0, and the total possible score ranged from 0 (homozygous for all lower DA alleles) to 4 (homozygous or heterozygous for all higher DA alleles).