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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Pain. 2018 May;159(5):919–928. doi: 10.1097/j.pain.0000000000001167

Figure 5. Nor-BNI administered into the left CeA prior to bright light stress (BLS) did not ameliorate the loss of DNIC.

Figure 5

Rats primed with morphine had a significant loss of DNIC following BLS in the left (A), right (B), and averaged (C) hindpaw measurements compared to vehicle-primed rats in both the vehicle and nor-BNI treatment groups. Administration of nor-BNI into the left CeA prior to BLS did not alter the loss of DNIC in the left (A), right (B), or averaged (C) hindpaw measurements. At the 20 minute DNIC timepoint (D) both morphine-primed groups have significantly less DNIC after BLS than saline-primed controls. *** p<0.001, ** p<0.01, * p<0.05 significant difference between the saline/vehicle group and other treatment groups. n= 10 saline/vehicle, 10 saline/nor-BNI, 6 morphine/vehicle, 6 morphine nor-BNI. Data analyzed by 3-way ANOVA with Sidak correction for multiple comparisons (A-C) or 2-way ANOVA followed by Tukey’s test for multiple comparisons (D).