Abstract
The hst‐1 gene, previously designated as the hst gene, and seven other oncogenes were examined for possible structural changes in esophageal, gastric and colorectal carcinomas by Southern blot hybridization. The hst‐1 gene was amplified in eight (42.1%) of the nineteen esophageal squamous cell carcinomas and in all four metastatic tumors of lymph nodes. The degree of amplification ranged from two to eight times. Coamplification of the hst‐1 and c‐erbB‐1 gene was found in one case of esophageal carcinoma. However, no amplification of the hst‐1 gene was detected in gastric and colorectal carcinomas.
Keywords: hst‐1, Amplification, Esophageal carcinoma
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