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Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1988 May;79(5):600–607. doi: 10.1111/j.1349-7006.1988.tb00029.x

Rearrangements of Chromosome 3 in Nonfamilial Renal Cell Carcinomas from Japanese Patients

Mitsuaki A Yoshida 1,✉, Tatsuro Ikeuchi 1, Yuichi Tachibana 2, Kentaro Takagi 2, Masatoshi Moriyama 3, Akira Tonomura 1
PMCID: PMC5917565  PMID: 3136112

Abstract

Cytogenetic studies were successfully carried out in 5 tumor tissues from Japanese patients with nonfamilial renal cell carcinoma, histologically diagnosed as clear cell subtype. Mitotic cells were obtained by a combined method of enzymatic disaggregation and short‐term culture (6–12 days). The modal chromosome numbers were found to be diploid or near‐diploid in all the cases examined. Every case showed characteristic structural and numerical abnormalities. Rearrangements in the short arm of chromosome 3 were observed as clonal abnormalities in all the cases, including a translocation t(3;6) resulting in a partial loss of 3p (3 cases), a terminal deletion of 3p (one case) and 2 different translocations involving 3p and 8p (one case). The other clonal abnormalities were a whole or partial trisomy of chromosome 7 and a loss of Y chromosome. The overall results in the present study were consistent with those of our previous data in American patients, and suggest that the rearrangements of chromosome 3 leading to a partial loss of its short arm may play primary and significant role(s) in the development of renal cell carcinoma.

Keywords: Chromosome rearrangement, Partial 3p deletion, Renal cell carcinoma

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References

  • 1).Sandberg , A. A. “ The Chromosomes in Human Cancer and Leukemia ” ( 1980. ). Elsevier North‐Holland, Inc. , New York . [Google Scholar]
  • 2).Mitelman , F. “ Catalog of Chromosome Aberrations in Cancer ” ( 1985. ). Allan R. Liss, Inc. , New York . [Google Scholar]
  • 3).Croce , C. M.Chromosome translocation and human cancer . Cancer Res. , 46 , 6019 – 6023 ( 1986. ). [PubMed] [Google Scholar]
  • 4).Wake , N. , Slocum , H. K. , Rustum , Y. M. , Matsui , S. I. and Sandberg , A. A.Chromosomes and causation of human cancer and leukemia. XLIV. A method for chromosome analysis of solid tumors . Cancer Genet. Cytogenet. , 3 , 1 – 10 ( 1981. ). [DOI] [PubMed] [Google Scholar]
  • 5).Cohen , A. J. , Li , F. P. , Berg , S. , Marchetto , D. J. , Tsai , S. , Jacobs , S. C. and Brown , R. S.Hereditary renal‐cell carcinoma associated with a chromosomal translocation . N. Engl. J. Med. , 301 , 592 – 595 ( 1979. ). [DOI] [PubMed] [Google Scholar]
  • 6).Pathak , S. , Strong , L. C. , Ferrell , R. E. and Trinidade , A.Familial renal cell carcinoma with a 3; 11 chromosome translocation limited to tumor cells . Science , 217 , 939 – 940 ( 1982. ). [DOI] [PubMed] [Google Scholar]
  • 7).Yoshida , M. A. , Ohyashiki , K. , Ochi , H. , Gibas , Z. , Pontes , J. E. , Prout , G. R.Jr. , Huben , R. and Sandberg , A. A.Cytogenetic studies of tumor tissues from patients with nonfamilial renal cell carcinoma . Cancer Res. , 46 , 2139 – 2147 ( 1986. ). [PubMed] [Google Scholar]
  • 8).Yoshida , M. A. , Ohyashiki , K. , Ochi , H. , Gibas , Z. , Prout , G. R. , Jr. , Pontes , E. J. , Huben , R. and Sandberg , A. A.Rearrangements of chromosome 3 in renal cell carcinoma . Cancer Genet. Cytogenet. , 19 , 351 – 354 ( 1986. ). [DOI] [PubMed] [Google Scholar]
  • 9).Berger , C. S. , Sandberg , A. A. , Todd , I. A. D. , Pennington , R. D. , Haddad , F. S. , Hecht , B. K. and Hecht , F.Chromosomes in kidney, ureter, and bladder cancer . Cancer Genet. Cytogenet. , 23 , 1 – 24 ( 1986. ). [DOI] [PubMed] [Google Scholar]
  • 10).Carroll , P. R. , Murty , V. V. S. , Reuter , V. , Jhanwar , S. , Fair , W. R. , Whitmore , W. F. and Chaganty , R. S. K.Abnormalities at chromosome region 3pl2‐14 characterize clear cell renal carcinoma . Cancer Genet. Cytogenet. , 26 , 253 – 259 ( 1987. ). [DOI] [PubMed] [Google Scholar]
  • 11).Kovacs , G. , Szücs , S. , DeRiese , W. and Baumgártel , H.Specific chromosome aberration in human renal cell carcinoma . Int. J. Cancer , 40 , 171 – 178 ( 1987. ). [DOI] [PubMed] [Google Scholar]
  • 12).Caspersson , T. , Lomakka , G. and Zech , L.The 24 fluorescence patterns of the human metaphase chromosomes—distinguishing characters and variability . Hereditas , 67 , 89 – 102 ( 1971. ). [DOI] [PubMed] [Google Scholar]
  • 13).Seabright , M.A rapid banding technique for human chromosomes . Lancet , ii , 971 ( 1971. ). [DOI] [PubMed] [Google Scholar]
  • 14. ) “ ISCN (1985): An International System for Human Cytogenetic Nomenclature ,” ed. Harnden D. G. and Klinger H. P. ( 1985. ). Karger; , Basel . [Google Scholar]
  • 15).Teyssier , J. R. , Henry , I. , Ferre , D. , Adnet , J. J. and Plout , M.Recurrent deletion of the short arm of chromosome 3 in human renal cell carcinoma: shift of the c‐raf I locus . J. Natl. Cancer Inst. , 77 , 1187 – 1195 ( 1986. ). [PubMed] [Google Scholar]
  • 16).Szücs , S. , Müller‐Brechlin , R. , DeRiese , W. and Kovacs , G.Deletion 3p: the chromosome loss in a primary renal cell carcinoma . Cancer Genet. Cytogenet. , 26 , 369 – 373 ( 1987. ). [DOI] [PubMed] [Google Scholar]
  • 17).Whang‐Peng , J. , Bunn , P. A. , Jr. , Kao‐Shan , C. S. , Lee , E. C. , Carney , D. N. , Gazdar , A. and Minna , J. D.A nonrandom chromosomal abnormality, del3p(14–23), in human small cell lung cancer (SCLC) . Cancer Genet. Cytogenet. , 6 , 119 – 134 ( 1982. ). [DOI] [PubMed] [Google Scholar]
  • 18).Wang , N. and Perkins , K. L.Involvement of band 3pl4 in t(3;8) hereditary renal carcinoma . Cancer Genet. Cytogenet. , 11 , 479 – 481 ( 1984. ). [DOI] [PubMed] [Google Scholar]
  • 19).Cavenee , W. K. , Dryja , T. P. , Phillips , R. A. , Benedict , W. F. , Godbout , R. , Gallie , B. L. , Murphree , A. L. , Strong , L. C. and White , R. L.Expression of recessive alleles by chromosomal mechanisms in retinoblastoma . Nature , 305 , 779 – 784 ( 1983. ). [DOI] [PubMed] [Google Scholar]
  • 20).Orkin , S. H. , Goldman , D. S. and Sallen , S. E.Development of homozygosity for chromosome 11p markers in Wilms' tumour . Nature 309 , 172 – 174 ( 1984. ). [DOI] [PubMed] [Google Scholar]
  • 21).Zbar , B. , Brauch , H. , Talmadge , C. and Linehan , M.Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma . Nature , 327 , 721 – 724 ( 1987. ). [DOI] [PubMed] [Google Scholar]
  • 22).Human Gene Mapping 8(1985); Eighth International Workshop on Human Gene Mapping . Cytogenet. Cell Genet. , 40 , Nos. 1–4 ( 1985. ). [PubMed] [Google Scholar]
  • 23).Hagiwara , M. , Chen , I‐L. , McGonile , R. , Beckman , B. , Hasten , F. H. and Fisher , J. W.Erythropoietin production in a primary culture of human renal carcinoma cells maintained in nude mice . Blood , 63 , 828 – 835 ( 1984. ). [PubMed] [Google Scholar]
  • 24).Sherwood , J. B. and Shouval , D.Continuous production of erythropoietin by an established human renal carcinoma cell line: development of the cell line . Proc. Natl. Acad. Sci. USA , 83 , 165 – 169 ( 1986. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 25).Law , M. L. , Chai , G‐Y. , Lin , F‐K. , Wei , Q. , Huang , S‐Z. , Hartz , J. H. , Morse , H. , Lin , C‐H. , Jones , C. and Kao , F‐T.Chromosomal assignment of the human erythropoietin gene and its DNA polymorphism . Proc. Natl. Acad. Sci. USA , 83 , 6920 – 6924 ( 1986. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 26).Korc , M. , Meltzer , P. and Trent , J.Enhanced expression of epidermal growth factor receptor correlates with alterations of chromosome 7 in human pancreatic cancer . Proc. Natl. Acad. Sci. USA , 83 , 5141 – 5144 ( 1986. ). [DOI] [PMC free article] [PubMed] [Google Scholar]

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