Skip to main content
Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1988 Jun;79(6):674–676. doi: 10.1111/j.1349-7006.1988.tb02220.x

NO CORRELATION BETWEEN L‐myc RESTRICTION FRAGMENT LENGTH POLYMORPHISM AND MALIGNANCY OF HUMAN COLORECTAL CANCERS

Isuzu Ikeda 1, Yukihito Ishizakz 1, Masako Ochiai 1, Ryuichi Sakai 1, Masayuki Itabashi 2, Masahiko Onda 3, Takashi Sugimura 1, Minako Nagao 1
PMCID: PMC5917581  PMID: 2900827

Abstract

The correlations of the restriction fragment length polymorphism (RFLP) pattern of L‐myc with the progressive state of cancer and metastases to lymph nodes or other organs were examined in 35 cases of human colorectal cancer by χ2 analysis. No significant correlation was found.

Keywords: L‐myc, Restriction fragment length polymorphism, Colorectal cancer

Full Text

The Full Text of this article is available as a PDF (158.2 KB).

REFERENCES

  • 1. ) Seeger , R. C , Brodeur , G. M. , Sather , H. , Dalton , A. , Siegel , S. E. , Wong , K. Y. and Hammond , D.Association of multiple copies on the N‐myc oncogene with rapid progression of neuroblastomas . N. Engl. J. Med. , 313 , 1111 – 1116 ( 1985. ). [DOI] [PubMed] [Google Scholar]
  • 2. ) Brodeur , G. M. and Seeger , R. C.Amplification of N‐myc in untreated human neuroblastomas correlates with advanced disease stage . Science , 224 , 1121 – 1124 ( 1984. ). [DOI] [PubMed] [Google Scholar]
  • 3. ) Schwab , M. , Ellison , J. , Busch , M. , Rosenau , W. , Varmus , H. E. and Bishop , J. M.Enhanced expression of the human gene N‐myc: consequent to amplification of DNA may contribute to malignant progression of neuroblastoma . Proc. Natl. Acad. Sci. USA , 81 , 4940 – 4944 ( 1984. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 4. ) Tanaka , T. , Slamon , D. J. , Shimoda , H. , Waki , C. , Kawaguchi , Y. , Tanaka , Y. and Ida , N.Expression of Ha‐ras oncogene products in human neuroblastomas and the significant correlation with a patient's prognosis . Cancer Res. , 48 , 1030 – 1034 ( 1988. ). [PubMed] [Google Scholar]
  • 5. ) Slamon , D. J. , Clark , G. M. , Wong , S. G , Levin , W. J. , Ullrich , A. and McGuire , W. L.Human breast cancer: correlation of relapse and survival with amplification of the HER‐2/neu oncogene . Science , 235 , 177 – 182 ( 1987. ). [DOI] [PubMed] [Google Scholar]
  • 6. ) Burt , R. W. , Bishop , T. , Cannon , L. A. , Dowdle , M. A. , Lee , R. G. and Skolnick , M. H.Dominant inheritance of adenomatous colonic polyps and colorectal cancer . N. Engl. J. Med. , 312 , 1540 – 1544 ( 1985. ). [DOI] [PubMed] [Google Scholar]
  • 7. ) Krontiris , T. G. , DiMartino , N. A. , Colb , M. and Parkinson , D. R.Unique allelic restriction fragments of the human Ha‐ras locus in leukocyte and tumour DNAs of cancer patients . Nature , 313 , 369 – 374 ( 1985. ). [DOI] [PubMed] [Google Scholar]
  • 8. ) Heighway , J. , Thatcher , N. , Cerny , T. and Hasleton , P. S.Genetic predisposition to human lung cancer . Br. J. Cancer , 53 , 453 – 457 ( 1986. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 9. ) Lidereau , R. , Escot , C. , Theillet , C. , Champeme , M. H. , Brunei , M. , Gest , J. and Callahan , R.High frequency of rare alleles of the human c‐Ha‐ras‐1 proto‐oncogene in breast cancer patients . J. Natl. Cancer Inst. , 77 , 697 – 701 ( 1986. ). [DOI] [PubMed] [Google Scholar]
  • 10. ) Lidereau , R. , Cole , S. T. , Larsen , C. J. and Mahul , D. M.A single point mutation responsible for c‐mos polymorphism in cancer patients . Oncogene , 1 , 235 – 237 ( 1987. ). [PubMed] [Google Scholar]
  • 11. ) Kawashima , K. , Shikama , H. , Imoto , K. , Izawa , M. , Naruke , T. , Okabayashi , K. and Nishimura , S.Close correlation between restriction fragment length polymorphism (RFLP) of the L‐myc gene and human lung cancer metastasis to the lymph nodes and other organs . Proc. Natl. Acad. Sci. USA , 85 , 2353 – 2356 ( 1988. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 12. ) Kawashima , K. , Imoto , K. , Izawa , M. , Naruke , T. , Okabayashi , K. , Sawada , T. , Moriya , N. , Hojo , K. , Konda , C. , Makuuchi , M. and Nishimura , S.Restriction fragment length polymorphism (RFLP) of L‐myc is related to the progression of human colon and stomach cancers . Proc. Jpn. Acad. , 63 , 300 – 303 ( 1987. ). [Google Scholar]
  • 13. ) Perucho , M. , Goldfarb , M. , Shimizu , K. , Lama , C. , Fogh , J. and Wigler , M.Human‐tumor‐derived cell lines contain common and different transforming genes . Cell , 27 , 467 – 476 ( 1981. ). [DOI] [PubMed] [Google Scholar]
  • 14. ) Southern , E. M.Detection of specific sequences among DNA fragments separated by gel electrophoresis . J. Mol. Biol. , 98 , 503 – 517 ( 1975. ). [DOI] [PubMed] [Google Scholar]
  • 15. ) Nau , M. M. , Brooks , B. J. , Battey , J. , Sausville , E. , Gazdar , A. F. , Kirsch , I. R. , McBride , O. W. , Bertness , V. , Hollis , G. F. and Minna , J. D.L‐myc, a new myc‐related gene amplified and expressed in human small cell lung cancer . Nature , 318 , 69 – 73 ( 1985. ). [DOI] [PubMed] [Google Scholar]
  • 16. ) Japanese Research Society for Cancer of Colon and Rectum . “ General Rules for Clinical and Pathological Studies on Cancer of Colon, Rectum and Anus ,” pp. 5 – 32 ( 1985. ). Kanehara Shuppan Co. , Tokyo ( in Japanese ). [Google Scholar]

Articles from Japanese Journal of Cancer Research : Gann are provided here courtesy of Wiley

RESOURCES