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- 1).Sporn , M. B. and Todaro , G. J.Autocrine secretion and malignant transformation of cells . N. Eng. J. Med. , 303 , 878 – 880 ( 1980. ). [DOI] [PubMed] [Google Scholar]
- 2).Ross , R. , Glomset , J. , Kariya , B. and Harker , L.A platelet‐dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro . Proc. Natl. Acad. Sci. USA , 71 , 1207 – 1210 ( 1974. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3).Heldin , C‐H. , Westermark , B. and Wasteson , A.Platelet‐derived growth factor: purification and partial characterization . Proc. Natl. Acad. Sci. USA , 76 , 3722 – 3726 ( 1979. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4).Heldin , C‐H. , Wasteson , A. and Westermark , B.Platelet‐derived growth factor . Mol Cell. Endocr. , 39 , 169 – 187 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 5).Antoniades , H. N. and Hunkapiller , M. W.Human platelet‐derived growth factor (PDGF): amino terminal amino acid sequence . Science , 220 , 963 – 965 ( 1983. ). [DOI] [PubMed] [Google Scholar]
- 6).Devare , S. G. , Reddy , E. P. , Law , J. D. , Robbins , K. C. and Aaronson , S. A.Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis . Proc. Natl. Acad. Sci. USA , 80 , 731 – 735 ( 1983. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 7).Waterfield , M. D. , Scrace , G. T. , Whittle , N. , Stroobant , P. , Johnsson , A. , Wasteson , A. , Westermark , B. , Heldin , C‐H. , Huang , J. S. and Deuel , T. F.Platelet‐derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus . Nature , 304 , 35 – 39 ( 1983. ). [DOI] [PubMed] [Google Scholar]
- 8).Doolittle , R. F. , Hunkapiller , M. W. , Hood , L. E. , Devare , S. G. , Robbins , K. C. , Aaronson , S. A. and Antoniades , H. N.Simian sarcoma virus onc gene, v‐sis, is derived from the gene (or genes) encoding a platelet‐derived growth factor . Science , 221 , 275 – 277 ( 1983. ). [DOI] [PubMed] [Google Scholar]
- 9).Johnsson , A. , Heldin , C‐H. , Wasteson , A. , Westermark , B. , Deuel , T. F. , Huang , J. S. , Seeburg , P. H. , Gray , E. , Ullrich , A. , Scarce , G. , Stroobant , P. and Waterfield , M. D.The c‐sis gene encodes a precursor of the B chain of platelet‐derived growth factor . EMBO J. , 3 , 921 – 928 ( 1984. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 10).Huang , J. S. , Huang , S. S. and Deuel , T. F.Transforming protein of simian sarcoma virus stimulates autocrine growth of SSV‐transformed cells through PDGF cell‐surface receptors . Cell , 39 , 79 – 87 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 11).Johnsson , A. , Betsholtz , C. , Heldin , C‐H. and Westermark , B.Antibodies to plateletderived growth factor inhibit acute transformation by simian sarcoma virus . Nature , 317 , 438 – 440 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 12).Clarke , M. F. , Westin , E. , Schmidt , D. , Josephs , S. F. , Ratner , L. , Wong‐Staal , F. , Gallo , R. C. and Reitz , M. S. , Jr.Transformation of NIH 3T3 cells by a human c‐sis cDNA clone . Nature , 308 , 464 – 467 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 13).Gazit , A. , Igarashi , H. , Chiu , I‐M. , Srinivasan , A. , Yaniv , A. , Tronick , S. R. , Robbins , K. C. and Aaronson , S. A.Expression of the normal human sis/PDGF‐2 coding sequence induces cellular transformation . Cell , 39 , 89 – 97 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 14).Betsholtz , C. , Westermark , B. , Ek , B. and Heldin , C‐H.Coexpression of a PDGF‐like growth factor and PDGF receptors in a human osteosarcoma cell line: implications for autocrine receptor activation . Cell , 39 , 447 – 457 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 15).Betsholtz , C. , Johnsson , A. , Heldin , C‐H. , Westermark , B. , Lind , P. , Urdea , M. S. , Eddy , R. , Shows , T. B. , Philpott , K. , Mellor , A. , Knott , T. J. and Scott , J.cDNA sequence and chromosomal localization of human platelet‐derived growth factor A chain and its expression in tumor cell lines . Nature , 320 , 695 – 699 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 16).Yarden , Y. , Escobedo , J. A. , Kuang , W‐J. , Yang‐Feng , T. L. , Daniel , T. O. , Tremble , P. M. , Chen , E. Y. , Ando , M. E. , Harkins , R. N. , Francke , U. , Fried , V. A. , Ullrich , A. and Williams , L. T.Structure of the receptor for platelet‐derived growth factor helps define a family of closely related growth factor receptors . Nature , 323 , 226 – 232 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 17).Cohen , S.Isolation of a submaxillary gland protein accelerating incisor eruption and eyelid opening in the nowborn animal . J. Biol. Chem. , 237 , 1555 – 1562 ( 1962. ). [PubMed] [Google Scholar]
- 18).Gray , A. , Dull , T. J. and Ullrich , A.Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000‐molecular weight protein precursor . Nature , 303 , 722 – 725 ( 1983. ). [DOI] [PubMed] [Google Scholar]
- 19).Scott , J. , Urdea , M. , Quiroga , M. , Sanchez‐Pescador , R. , Fong , N. , Selby , M. , Rutter , W. J. and Bell , G. I.Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins . Science , 221 , 236 – 240 ( 1983. ). [DOI] [PubMed] [Google Scholar]
- 20).De Larco , J. and Todaro , G. J.Growth factors from murine sarcoma virus‐transformed cells . Proc. Natl. Acad. Sci. USA , 75 , 4001 – 4005 ( 1978. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 21).Derynck , R. , Roberts , A. B. , Winkler , M. E. , Chen , E. Y. and Goeddel , D. V.Human transforming growth factor‐α: precursor structure and expression in E. coli. Cell , 38 , 287 – 297 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 22).Lee , D. C. , Rose , T. M. and Todaro , G. J.Cloning and sequence analysis of a cDNA for rat transforming growth factor‐α . Nature , 313 , 489 – 491 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 23).Carpenter , G. , Stoscheck , C. M. , Preston , Y. A. and De Larco , J. E.Antibodies to the epidermal growth factor receptor block the biological activities of sarcoma growth factor . Proc. Natl. Acad. Sci. USA , 80 , 5627 – 5630 ( 1983. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 24).Massague , J.Epidermal growth factor‐like transforming growth factor. II. Interactions with epidermal growth factor receptors in human placenta membranes and A431 cells . J. Biol Chem. , 258 , 13614 – 13620 ( 1983. ). [PubMed] [Google Scholar]
- 25).Lee , D. C. , Rochford , R. M. , Todaro , G. J. and Villareal , L. P.Developmental expression of rat transforming growth factor‐α mRNA . Mol. Cell. Biol. , 5 , 3644 – 3646 ( 1985. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 26).Ullrich , A. , Coussens , L. , Hayflick , J. S. , Dull , T. J. , Gray , A. , Tarn , A. W. , Lee , J. , Yarden , Y. , Libermann , T. A. , Schlessinger , J. , Downward , J. , Mayes , E. L. V. , Whittle , N. , Waterfield , M. D. and Seeburg , P. H.Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells . Nature , 309 , 418 – 425 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 27).Yamamoto , T. , Nishida , T. , Miyajima , N. , Kawai , S. , Ooi , T. and Toyoshima , K.The erbB gene of avian erythroblastosis virus is a member of the src gene family . Cell , 35 , 71 – 78 ( 1983. ). [DOI] [PubMed] [Google Scholar]
- 28).Downward , J. , Yarden , Y. , Mayes , E. , Scrace , G. , Totty , N. , Stockwell , P. , Ullrich , A. , Schlessinger , J. and Waterfield , M. D.Close similarity of epidermal growth factor receptor and v‐erbB oncogene protein sequences . Nature , 307 , 521 – 527 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 29).Kris , R. M. , Lax , I. , Gullick , W. , Waterfield , M. D. , Ullrich , A.Fridkin , M. and Schlessinger , J.Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v‐erbB protein . Cell , 40 , 619 – 625 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 30).Xu , Y. H. , Richert , N. , Ito , S. , Merlino , G. T. and Pastan , I.Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines . Proc. Natl. Acad. Sci. USA , 81 , 7308 – 7312 ( 1984. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 31).King , C. R. , Kraus , M. H. , Williams , L. T. , Merlino , G. T. , Pastan , I. and Aaronson , S. A.Human tumor cell lines with EGF receptor gene amplification in the absence of aberrant sized mRNAs . Nucleic Acids Res. , 13 , 8447 – 8486 ( 1985. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 32).Libermann , T. A. , Nusbaum , H. R. , Razon , N. , Kris , R. , Lax , I. , Soreq , H. , Whittle , N. , Waterfield , M. D. , Ullrich , A. and Schlessinger , J.Amplification, enhanced expression, and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin . Nature , 313 , 144 – 147 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 33).Yamamoto , T. , Kamata , N. , Kawano , H. , Shimizu , S. , Kuroki , T. , Toyoshima , K. , Rikimaru , K. , Nomura , N. , Ishizaki , R. , Pastan , I. , Gamou , S. and Shimizu , N.High incidence of amplification of the epidermal growth factor receptor gene in human squamous carcinoma cell lines . Cancer Res. , 46 , 414 – 416 ( 1986. ). [PubMed] [Google Scholar]
- 34).Veru , T. J. , Beguinot , L. , Vass , W. C. , Willingham , M. C. , Merlino , G. T. , Pastan , I. and Lowy , D. R.Epidermal growth factor‐dependent transformation by a human EGF receptor proto‐oncogene . Science , 238 , 1408 – 1410 ( 1987. ). [DOI] [PubMed] [Google Scholar]
- 35).Di Fiore , P. P. , Pierce , J. H. , Fleming , T. P. , Hazan , R. , Ullrich , A. , King , C. R. , Schlessinger , J. and Aaronson , S. A.Over‐expression of the human EGF receptor confers an EGF‐dependent transformed phenotype to NIH 3T3 cells . Cell , 51 , 1063 – 1070 ( 1987. ). [DOI] [PubMed] [Google Scholar]
- 36).Coussens , L. , Yang‐Feng , T. L. , Liao , Y‐C. , Chen , E. , Gray , A. , McGrath , J. , Seeburg , P. H. , Libermann , T. A. , Schlessinger , J. , Francke , U. , Levinson , A. and Ullrich , A.Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene . Science , 230 , 1132 – 1139 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 37).Yamamoto , T. , Ikawa , S. , Akiyama , T. , Semba , K. , Nomura , N. , Miyajima , N. , Saito , T. and Toyoshima , K.Similarity of protein encoded by the human c‐erbB‐2 gene to epidermal growth factor receptor . Nature , 319 , 230 – 234 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 38).Schechter , A. L. , Stern , D. F. , Vaidysanathan , L. , Decker , S. J.Drebin , J. A. , Greene , M. I. and Weinberg , R. A.The neu oncogene: an erbB‐related gene encoding a 185,000‐Mr tumour antigen . Nature , 312 , 513 – 516 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 39).Yokota , J. , Yamamoto , T. , Toyoshima , K. , Terada , M. , Sugimura , T. , Battifora , H. and Cline , M. J.Amplification of c‐erbB‐2 oncogene in human adenocarcinomas in vivo . Lancet , 1 , 765 – 767 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 40).Kraus , M. H. , Popescu , N. C. , Amsbaugh , S. C. and King , C. R.Over‐expression of the EGF receptor‐related proto‐oncogene erbB‐2 in human mammary tumor cell lines by different molecular mechanisms . EMBO J. , 6 , 605 – 610 ( 1987. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 41).Slamon , D. J. , Clark , G. M. , Wong , S. G. , Levin , W. J. , Ullrich , A. and McGuire , W. L.Human breast cancer: correlation of relapse and survival with amplification of the HER‐2/neu oncogene . Science , 235 , 177 – 182 ( 1987. ). [DOI] [PubMed] [Google Scholar]
- 42).Di Fiore , P. P. , Pierce , J. H. , Kraus , M. H. , Segatto , O. , King , C. R. and Aaronson , S. A.erbB‐2 is a potent oncogene when overexpressed in NIH/3T3 cells . Science , 237 , 178 – 182 ( 1987. ). [DOI] [PubMed] [Google Scholar]
- 43).Bargmann , C. I. , Hung , M‐C. and Weinberg , R. A.Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185 . Cell , 45 , 649 – 657 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 44).Cuttitta , F. , Carney , D. N. , Mulshine , J. , Moody , T. W. , Fedorko , J. , Fischler , A. and Minna , J. D.Bombesin‐like peptides can function as autocrine growth factors in human small‐cell lung cancer . Nature , 316 , 823 – 826 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 45).Rozengurt , E. and Sinnett‐Smith , J.Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells . Proc. Natl. Acad. Sci. USA , 80 , 2936 – 2940 ( 1983. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 46).Willey , J. C. , Lechner , J. F. and Harris , C. C.Bombesin and the C‐terminal tetradecapeptide of gastrin‐releasing peptide are growth factors for normal human bronchial epithelial cells . Exp. Cell Res. , 153 , 245 – 248 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 47).Folkman , J. and Klagsbrun , M.Angiogenic factors . Science , 235 , 442 – 447 ( 1987. ). [DOI] [PubMed] [Google Scholar]
- 48).Taira , M. , Yoshida , T. , Miyagawa , K. , Sakamoto , H. , Terada , M. and Sugimura , T.cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity . Proc. Natl. Acad. Sci. USA , 84 , 2980 – 2984 ( 1987. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 49).Delli Bovi , P. , Curatola , A. M. , Kern , F. G. , Greco , A. , Ittmann , M. , and Basilico , C.An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the EGF family . Cell , 50 , 729 – 737 ( 1987. ). [DOI] [PubMed] [Google Scholar]
- 50).Yoshida , T. , Miyagawa , K. , Odagiri , H. , Sakamoto , H. , Little , P. F. R. , Terada , M. and Sugimura , T.Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int‐2‐encoded protein . Proc. Natl. Acad. Sci. USA , 84 , 7305 – 7309 ( 1987. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 51).Koda , T. , Sasaki , A. , Matsushima , S. and Kakinuma , M.A transforming gene, hst, found in NIH 3T3 cells transformed with DNA from three stomach cancers and a colon cancer . Jpn. J. Cancer Res. (Gann) , 78 , 325 – 328 ( 1987. ). [PubMed] [Google Scholar]
- 52).Abraham , J. A. , Mergia , A. , Whang , J. L. , Tumolo , A. , Friedman , J. , Hjerrild , K. A. , Gospodarowicz , D. and Fiddes , J. C.Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor . Science , 233 , 545 – 548 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 53).Rogelj , S. , Weinberg , R. A. , Fanning , P. and Klagsbrun , M.Basic fibroblast growth factor fused to a signal peptide transforms cells . Nature , 331 , 173 – 175 ( 1988. ). [DOI] [PubMed] [Google Scholar]
- 54).Moore , R. , Casey , G. , Brookes , S. , Dixon , M. , Peters , G. and Dickson , C.Sequence, topography and protein coding potential of mouse int‐2: a putative oncogene activated by mouse mammary tumour virus . EMBO J. , 5 , 919 – 924 ( 1986. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 55).Moses , H. L. , Branum , E. B. , Proper , J. A. and Robinson , R. A.Transforming growth factor production by chemically transformed cells . Cancer Res. , 41 , 2842 – 2848 ( 1981. ). [PubMed] [Google Scholar]
- 56).Tucker , R. F. , Shipley , G. D. , Moses , H. L. and Holley , R. W.Growth inhibitor from BSC‐ 1 cells closely related to type β transforming growth factor . Science , 226 , 705 – 707 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 57).Roberts , A. B. , Anzano , M. A. , Wakefield , L. M. , Roche , N. S. , Stern , D. F. and Sporn , M. B.Type β transforming growth factor: a bifunctional regulator of cellular growth . Proc. Natl. Acad. Sci. USA , 82 , 119 – 123 ( 1985. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 58).Sporn , M. B. and Roberts , A. B.Autocrine growth factors and cancer . Nature , 313 , 745 – 747 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 59).Knabbe , C. , Lippman , M. E. , Wakefield , L. M. , Flanders , K. C. , Kasid , A. , Derynck , R. and Dickson , R. B.Evidence that transforming growth factor‐β is a hormonally regulated negative growth factor in human breast cancer cells . Cell , 48 , 417 – 428 ( 1987. ). [DOI] [PubMed] [Google Scholar]
- 60).Shipley , C. D. , Pittelkow , M. R. , Wille , J. J. , Jr. , Scott , R. E. and Moses , H. L.Reversible inhibition of normal human prokeratinocyte proliferation by type‐β‐transforming growth factor/growth inhibitor in serum‐free medium . Cancer Res. , 46 , 2068 – 2071 ( 1986. ). [PubMed] [Google Scholar]
- 61).Metcalf , D. “ The Hemopoietic Colony Stimulating Factors ” ( 1984. ). Elsevier; , Amsterdam . [Google Scholar]
- 62).Clark , S. C. and Kamen , R.The human hematopoietic colony‐stimulating factors . Science , 236 , 1229 – 1237 ( 1987. ). [DOI] [PubMed] [Google Scholar]
- 63).Lang , R. A. , Metcalf , D. , Gough , N. M. , Dunn , A. R. and Gonda , T. J.Expression of a hematopoietic growth factor cDNA in a factor‐dependent cell line results in autonomous growth and tumorigenicity . Cell , 43 , 531 – 542 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 64).Lang , R. A. , Metcalf , D. , Cuthbertson , R. A. , Lyons , I. , Stanley , E.Kelso , A. , Kannourakis , G. , Williamson , D. J. , Klintworth , G. K. , Gonda , T. J. and Dunn , A. R.Transgenic mice expressing a hemopoietic growth factor gene (GM‐CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage . Cell , 51 , 675 – 686 ( 1987. ). [DOI] [PubMed] [Google Scholar]
- 65).Wong , G. G. , Temple , P. A. , Leary , A. C. , Witek‐Giannotti , J. S. , Yang , Y‐C. , Ciarletta , A. B. , Chung , M. , Murtha , P. , Kriz , R. , Kaufman , R. J. , Ferenz , C. R. , Sibley , B. S. , Turner , K. J. , Hewick , R. M. , Clark , S. C. , Yanai , N. , Yokota , H. , Yamada , M. , Saito , M. , Motoyoshi , K. and Takaku , F.Human CSF‐1: molecular cloning and expression of 4‐kb cDNA encoding the human urinary protein . Science , 235 , 1504 – 1508 ( 1987. ). [DOI] [PubMed] [Google Scholar]
- 66).Roussel , M. F. , Rettenmier , C. W. , Look , A. T. and Sherr , C. J.Cell surface expression of v‐fms‐encoded glycoproteins is required for transformation . Mol. Cell. Biol. , 4 , 1999 – 2009 ( 1984. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 67).Rettenmier , C. W. , Chen , J. H. , Roussel , M. F. and Sherr , C. J.The product of the c‐fms proto‐oncogene: a glycoprotein with associated tyrosine kinase activity . Science , 228 , 320 – 322 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 68).Besmer , P. , Murphy , J. E. , George , P. C. , Qiu , F. , Bergold , P. J. , Lederman , L. , Snyder , H. W. , Jr. , Brodeur , D. , Zuckerman , E. E. and Hardy , W. D.A new acute transforming feline retrovirus and relationship of its oncogene v‐kit with the protein kinase gene family . Nature , 320 , 415 – 421 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 69).Sherr , C. J. , Rettenmier , C. W. , Sacca , R. , Roussel , M. F. , Look , A. T. and Stanley , E. R.The c‐fms proto‐oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF‐1 . Cell , 41 , 665 – 676 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 70).Roussel , M. F. , Dull , T. J. , Rettenmier , C. W. , Ralph , P. , Ullrich , A. and Sherr , C. J.Transforming potential of the c‐fms protooncogene (CSF‐1 receptor) . Nature , 325 , 549 – 552 ( 1987. ). [DOI] [PubMed] [Google Scholar]
- 71).Heard , J. M. , Roussel , M. F. , Rettenmier , C. W. and Sherr , C. J.Multilineage hematopoietic disorders induced by transplantation of bone marrow cells expressing the v‐fms oncogene . Cell , 51 , 663 – 673 ( 1987. ). [DOI] [PubMed] [Google Scholar]
- 72).Lomedico , P. T. , Gubler , U. , Hellmann , C. P. , Dukovich , M. , Giri , J. G. , Pan , Y‐C. E. , Collier , K. , Semionow , R. , Chua , A. O. and Mizel , S. B.Cloning and expression of murine interleukin‐1 cDNA in Escherichia coli . Nature , 312 , 458 – 462 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 73).Auron , P. E. , Webb , A. C. , Rosenwasser , L. J. , Mucci , S. F. , Rich , A. , Wolff , S. M. and Dinarello , C. A.Nucleotide sequence of human monocyte interleukin 1 precursor cDNA . Proc. Natl. Acad. Sci. USA , 81 , 7907 – 7911 ( 1984. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 74).Dower , S. K. , Kronheim , S. R. , March , C. J. , Conlon , P. J. , Hopp , T. P. , Gills , S. and Urdal , D. L.Detection and characterization of high affinity plasma membrane receptors for human interleukin‐1 . J. Exp. Med. , 162 , 501 – 515 ( 1985. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 75).Bird , T. A. and Saklatvala , J.Identification of a common class of high‐affinity receptors for both types of porcine interleukin‐1 on connective tissue cells . Nature , 324 , 263 – 266 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 76).Dower , S. K. , Kronheim , S. R. , Hopp , T. P. , Cantrell , M. , Deeley , M. , Gillis , S. , Henney , C. S. and Urdal , D. L.The cell surface receptors for interleukin‐lα and interleukin‐1β are identical . Nature , 324 , 266 – 268 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 77).Onozaki , K. , Matsushima , K. , Aggarwal , B. B. and Oppenheim , J. J.Human interleukin 1 is a cytocidal factor for several tumor cell lines . J. Immunol. , 135 , 3962 – 3968 ( 1985. ). [PubMed] [Google Scholar]
- 78).Lachman , L. B. , Dinarello , C. A. , Llansa , N. D. and Fidler , I. J.Natural and recombinant human interleukin‐1β is cytotoxic for human melanoma cells . J. Immunol. , 136 , 3098 – 3102 ( 1986. ). [PubMed] [Google Scholar]
- 79).Lachman , L. B. , Brown , D. C. and Dinarello , C. A.Growth‐promoting effect of recombinant interleukin‐1 and tumor necrosis factor for a human astrocytoma cell line . J. Immunol. , 138 , 2913 – 2916 ( 1987. ). [PubMed] [Google Scholar]
- 80).Morgan , D. A. , Ruscetti , F. W. and Gallo , R. C.Selective in vitro growth of T‐lymphocytes from normal human bone marrows . Science , 193 , 1007 – 1008 ( 1976. ). [DOI] [PubMed] [Google Scholar]
- 81).Smith , K. A.Interleukin 2 . Annu. Rev. Immunol. , 2 , 319 – 333 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 82).Taniguchi , T. , Matsui , H. , Fujita , T. , Hatakeyama , M. , Kashima , N. , Fuse , A. , Hanuro , J. , Nishi‐Takaoka , C. and Yamada , G.Molecular analysis of the interleukin‐2 system . Immunol. Rev. , 92 , 121 – 133 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 83).Taniguchi , T. , Matsui , H. , Fujita , T. , Takaoka , C. , Kashima , N. , Yoshimoto , R. and Hamuro , J.Structure and expression of a cloned cDNA for human interleukin‐2 . Nature , 302 , 305 – 310 ( 1983. ). [DOI] [PubMed] [Google Scholar]
- 84).Fujita , T. , Takaoka , C. , Matsui , H. and Taniguchi , T.Structure of the human interleukin 2 gene . Proc. Natl. Acad. Sci. USA , 80 , 7437 – 7441 ( 1983. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 85).Seigel , L. J. , Harper , M. E. , Wong‐Staal , F. , Gallo , R. C. , Nash , W. G. and O'Brien , S. J.Gene for T‐cell growth factor: location on human chromosome 4q and feline chromosome B1 . Science , 223 , 175 – 178 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 86).Uchiyama , T. , Broder , S. and Waldmann , T. A.A monoclonal antibody (anti‐Tac) reactive with activated and functionally mature human T cells. I. Production of anti‐Tac monoclonal antibody and distribution of Tac(+) cells . J. Immunol. , 126 , 1393 – 1397 ( 1981. ). [PubMed] [Google Scholar]
- 87).Leonard , W. J. , Depper , J. M. , Uchiyama , T. , Smith , K. A. , Waldmann , T. A. and Greene , W. C.A monoclonal antibody that appears to recognize the receptor for human T cell growth factor; partial characterization of the receptor . Nature , 300 , 267 – 269 ( 1982. ). [DOI] [PubMed] [Google Scholar]
- 88).Leonard , W. J. , Depper , J. M. , Crabtree , G. R. , Rudikoff , S. , Pumphrey , J. , Robb , R. J. , Svetlik , P. B. , Peffer , N. , Waldmann , T. A. and Greene , W. C.Molecular cloning and expression of cDNAs for the human interleukin‐2 receptor . Nature , 311 , 626 – 631 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 89).Nikaido , T. , Shimizu , A. , Ishida , N. , Sabe , H. , Teshigawara , K. , Maeda , M. , Uchiyama , T. , Yodoi , J. and Honjo , T.Molecular cloning of cDNA encoding human interleukin‐2 receptor . Nature , 311 , 631 – 635 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 90).Cosman , D. , Ceretti , D. P. , Larsen , A. , Park , L. , March , C. , Dower , S.Gillis , S. and Urdal , D.Cloning, sequence and expression of human interleukin‐2 receptor . Nature , 312 , 768 – 771 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 91).Fujita , T. , Shibuya , H. , Ohashi , T. , Yamanishi , K. and Taniguchi , T.Regulation of human interleukin‐2 gene: functional DNA sequences in the 5′ flanking region for the gene expression in activated T lymphocytes . Cell , 46 , 401 – 407 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 92).Maruyama , M. , Shibuya , H. , Harada , H. , Hatakeyama , M. , Seiki , M. , Fujita , T. , Inoue , J‐I. , Yoshida , M. and Taniguchi , T.Evidence for aberrant activation of the interleukin‐2 autocrine loop by HTLV‐1‐encoded p40x and T3/Ti complex triggering . Cell , 48 , 343 – 350 ( 1987. ). [DOI] [PubMed] [Google Scholar]
- 93).Cross , S. L. , Feinberg , M. B. , Wolf , J. B. , Holbrook , N. J. , Wong‐Staal , F. and Leonard , W. J.Regulation of the human interleukin‐2 receptor α chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV‐1 . Cell , 49 , 47 – 56 ( 1987. ). [DOI] [PubMed] [Google Scholar]
- 94).Robb , R. J. , Greene , W. C. and Rusk , C. M.Low and high affinity cellular receptors for interleukin‐2: implications for the level of Tac antigen . J. Exp. Med. , 160 , 1126 – 1146 ( 1984. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 95).Hatakeyama , M. , Minamoto , S. , Uchiyama , T. , Hardy , R. R. , Yamada , G. and Taniguchi , T.Reconstitution of functional receptor for human interleukin‐2 in mouse cells . Nature , 318 , 467 – 470 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 96).Kondo , S. , Shimizu , A. , Maeda , M. , Tagaya , Y. , Yodoi , J. and Honjo , T.Expression of functional human interleukin‐2 receptor in mouse T cells by cDNA transfection . Nature , 320 , 75 – 77 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 97).Robb , R. J.Conversion of low‐affinity interleukin‐2 receptors to a high‐affinity state following fusion of cell membranes . Proc. Natl. Acad. Sci. USA , 83 , 3992 – 3996 ( 1986. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 98).Hatakeyama , M. , Minamoto , S. and Taniguchi , T.Intracytoplasmic phosphorylation sites of Tac antigen (p55) are not essential for the conformation, function, and regulation of the human interleukin 2 receptor . Proc. Natl. Acad. Sci. USA , 83 , 9650 – 9654 ( 1986. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 99).Hatakeyama , M. , Doi , T. , Kono , T. , Maruyama , M. , Minamoto , S. , Mori , H. , Kobayashi , H. , Uchiyama , T. and Taniguchi , T.Transmembrane signaling of interleukin 2 receptor: conformation and function of human interleukin 2 receptor (p55)/insulin receptor chimeric molecules . J. Exp. Med. , 166 , 362 – 375 ( 1987. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 100).Sharon , M. , Klausner , R. D. , Cullen , B. R. , Chizzonite , R. and Leonard , W. J.Novel interleukin‐2 receptor subunit detected by cross‐linking under high‐affinity conditions . Science , 234 , 859 – 863 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 101).Tsudo , M. , Kozak , R. W. , Goldman , C. K. and Waldmann , T. A.Demonstration of a non‐Tac peptide that binds interleukin 2: a potential participant in a multi‐chain interleukin 2 receptor complex . Proc. Natl. Acad. Sci. USA , 83 , 9694 – 9698 ( 1986. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 102).Teshigawara , K. , Wang , H‐M. , Kato , K. and Smith , K. A.Interleukin 2 high‐affinity receptor expression requires two distinct binding proteins . J. Exp. Med. , 165 , 223 – 238 ( 1987. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 103).Hattori , T. , Uchiyama , T. , Toibana , T. , Takatsuki , K. and Uchino , H.Surface phenotype of Japanese adult T‐cell leukemia cells characterized by monoclonal antibodies . Blood , 58 , 645 – 647 ( 1981. ). [PubMed] [Google Scholar]
- 104).Yoshida , M. , Miyoshi , I. and Hinuma , Y.Isolation and characterization of retrovirus from cell lines of human adult T‐cell leukemia and its implication in the disease . Proc. Natl. Acad. Sci. USA , 79 , 2031 – 2035 ( 1982. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 105).Seiki , M. , Hattori , S. , Hirayama , Y. and Yoshida , M.Human adult T‐cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA . Proc. Natl. Acad. Sci. USA , 80 , 3618 – 3622 ( 1983. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 106).Miyoshi , I. , Kubonishi , I. , Yoshimoto , S. , Akagi , T. , Ohtsuki , Y. , Shiraishi , Y. , Nagata , K. and Hinuma , Y.Type C virus particles in a cord T‐cell line derived by co‐cultivating normal human cord leukocytes and human leukaemic T cells . Nature , 294 , 770 – 771 ( 1981. ). [DOI] [PubMed] [Google Scholar]
- 107).Gootenberg , J. E. , Ruscetti , F. W. , Mier , J. W. , Gazdar , A. and Gallo , R. C.Human cutaneous T cell lymphoma and leukemia cell lines produce and respond to T cell growth factor . J. Exp. Med. , 154 , 1403 – 1418 ( 1981. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 108).Arya , S. K. , Wong‐Staal , F. and Gallo , R. C.T‐cell growth factor gene: lack of expression in human T‐cell leukemia‐lymphoma virus‐infected cells . Science , 223 , 1086 – 1087 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 109).Sodroski , J. G. , Rosen , C. A. and Haseltine , W. A.Trans‐acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells . Science , 225 , 381 – 385 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 110).Fujisawa , J. , Seiki , M. , Kiyokawa , T. and Yoshida , M.Functional activation of the long terminal repeat of human T‐cell leukemia virus type I by a trans‐acting factor . Proc. Natl. Acad. Sci. USA , 82 , 2277 – 2281 ( 1985. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 111).Sodroski , J. , Rosen , C. , Goh , W. C. and Haseltine , W.A transcriptional activator protein encoded by the x‐lor region of the human T‐cell leukemia virus . Science , 228 , 1430 – 1434 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 112).Fujisawa , J. , Seiki , M. , Sato , M. and Yoshida , M.A transcriptional enhancer sequence of HTLV‐1 is responsible for trans‐activation mediated by p40x of HTLV‐1 . EMBO J. , 5 , 713 – 718 ( 1986. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 113).Inoue , J. , Seiki , M. , Taniguchi , T. , Tsuru , S. and Yoshida , M.Induction of interleukin 2 receptor gene expression by p40x encoded by human T‐cell leukemia virus type 1 . EMBO J. , 5 , 2883 – 2888 ( 1986. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 114).Matsuoka , M. , Hattori , T. , Chosa , T. , Tsuda , H. , Kuwata , S. , Yoshida , M. , Uchiyama , T. and Takatsuki , K.T3 surface molecules on adult T cell leukemia cells are modulated in vivo . Blood , 67 , 1070 – 1076 ( 1986. ). [PubMed] [Google Scholar]
- 115).Arima , N. , Daitoku , Y. , Yamamoto , Y. , Fujimoto , K. , Ohgaki , S. , Kojima , K. , Fukumori , J. , Matsushita , K. , Tanaka , H. and Onoue , K.Heterogeneity in response to interleukin 2 and interleukin 2‐producing ability of adult T cell leukemic cells . J. Immunol. , 138 , 3069 – 3074 ( 1987. ). [PubMed] [Google Scholar]
- 116).Yamada , G. , Kitamura , Y. , Sonoda , H. , Harada , H. , Taki , S. , Mulligan , R. C. , Osawa , H. , Diamantstein , T. , Yokoyama , S. and Taniguchi , T.Retroviral expression of the human IL‐2 gene in a murine T cell line results in cell growth autonomy and tumorigenicity . EMBO J. , 6 , 2705 – 2709 ( 1987. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 117).Duprez , V. , Lenoir , G. and Dautry‐Varsat , A.Autocrine growth stimulation of a human T‐cell lymphoma line by interleukin 2 . Proc. Natl. Acad. Sci. USA , 82 , 6932 – 6936 ( 1985. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 118).Ihle , J. N. , Pepersack , L. and Rebar , L.Regulation of T cell differentiation: in vitro induction of 20α‐hydroxysteroid dehydrogenase in splenic lymphocytes is mediated by a unique lymphokine . J. Immunol. , 126 , 2184 – 2190 ( 1981. ). [PubMed] [Google Scholar]
- 119).Yokota , T. , Lee , F. , Rennick , D. , Hall , C. , Arai , N. , Mosmann , T. , Nabel , G. , Cantor , H. and Arai , K.Isolation and characterization of a mouse cDNA clone that expresses mast‐cell growth factor activity in monkey cells . Proc. Natl. Acad. Sci. USA , 81 , 1070 – 1074 ( 1984. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 120).Rennick , D. M. , Lee , F. D. , Yokota , T. , Arai , K. , Cantor , H. and Nabel , G.A cloned MCGF cDNA encodes a multilineage hematopoietic growth factor: multiple activities of interleukin 3 . J. Immunol. , 134 , 910 – 914 ( 1985. ). [PubMed] [Google Scholar]
- 121).Hapel , A. J. , Vande Woude , G. , Campbell , M. D. , Young , I. G. and Robins , T.Generation of an autocrine leukaemia using a retro viral expression vector carrying the interleukin‐3 gene . Lymphokine Res. , 5 , 249 – 254 ( 1986. ). [PubMed] [Google Scholar]
- 122).Howard , M. , Farrer , J. , Hilfiker , M. , Johnson , B. , Takatsu , K. and Paul , W.Identification of a T cell‐derived B cell growth factor distinct from interleukin 2 . J. Exp. Med. , 155 , 914 – 923 ( 1982. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 123).Noma , Y. , Sideras , P. , Naito , T. , Bergstedt‐Lindquist , S. , Azuma , C. , Severinson , E. , Tanabe , T. , Kinashi , T. , Matsuda , F. , Yaoita , Y. and Honjo , T.Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter . Nature , 319 , 640 – 646 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 124).Lee , F. , Yokota , T. , Otsuka , T. , Meyerson , P. , Villaret , D. , Coffman , R. , Mosmann , T. , Rennick , D. , Roehm , N. , Smith , G. , Zlotnik , A. and Arai , K.Isolation and characterization of a mouse interleukin cDNA clone that expresses B‐cell stimulatory factor 1 activities and T‐cell and mast‐cell‐stimulating activities . Proc. Natl. Acad. Sci. USA , 83 , 2061 – 2065 ( 1986. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 125).Schimple , A. and Wecker , E.Replacement of T cell function by a T cell product . Nature, New Biol. , 273 , 15 – 17 ( 1972. ). [DOI] [PubMed] [Google Scholar]
- 126).Kinashi , T. , Harada , N. , Severinson , E. , Tanabe , T. , Sideras , P. , Konishi , M. , Azuma , C. , Tominaga , A. , Bergstedt‐Lindquist , S. , Takahashi , M. , Matsuda , F. , Yaoita , Y. , Takatsu , K. and Honjo , T.Cloning of complementary DNA encoding T cell replacing factor and identify with B cell growth factor II . Nature , 324 , 70 – 73 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 127).Campbell , H. D. , Tucker , W. Q. , Hort , Y. , Martinson , M. E. , Mayo , G. , Clutterbuck , E. J. , Sanderson , C. J. and Young , I. G.Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5) . Proc. Natl. Acad. Sci. USA , 84 , 6629 – 6633 ( 1987. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 128).Hirano , T. , Yasukawa , K. , Harada , H. , Taga , T. , Watanabe , Y. , Matsuda , T. , Kashiwamura , S. , Nakajima , K. , Koyama , K. , Iwamatsu , A. , Tsunasawa , S. , Sakiyama , F. , Matsui , H. , Takahara , Y. , Taniguchi , T. and Kishimoto , T.Complementary DNA for a novel human interleukin (BSF‐2) that induces B lymphocytes to produce immunoglobulin . Nature , 324 , 73 – 76 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 129).Zilberstein , A. , Ruggieri , R. , Korn , J. H. and Revel , M.Structure and expression of cDNA and genes for human interferon‐β, a distinct species inducible by growth‐stimulatory cytokines . EMBO J. , 5 , 2529 – 2537 ( 1986. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 130).Haegeman , G. , Content , J. , Volckaert , G. , Derynck , R. , Tavernier , J. and Fiers , W.Structural analysis of the sequence encoding for an inducible 26‐kDa protein in human flbroblasts . Eur. J. Biochem. , 159 , 625 – 632 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 131).Gauldie , J. , Richards , C. , Harnish , D. , Lansdorp , P. and Baumann , H.Interferon β/2B‐cell stimulatory factor type 2 shares identity with monocyte‐derived hepatocyte‐stimulating factor and regulates the major acute phase protein response in liver cells . Proc. Natl. Acad. Sci. USA , 84 , 7251 – 7255 ( 1987. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 132).Ikebuchi , K. , Wong , G. G. , Clark , S. C. , Ihle , J. N. , Hirai , Y. and Ogawa , M.Interleukin 6 enhancement of interleukin 3‐dependent proliferation of multipotential hemopoietic progenitors . Proc. Natl. Acad. Sci. USA , 84 , 9035 – 9039 ( 1987. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 133).Kawano , M. , Hirano , T. , Matsuda , T. , Taga , T. , Horii , Y. , Iwato , K. , Asaoku , H. , Tang , B. , Tanabe , O. , Tanaka , H. , Kuramoto , A. and Kishimoto , T.Autocrine generation and requirement of BSF‐2/IL‐6 for human multiple myelomas . Nature , 332 , 83 – 85 ( 1988. ). [DOI] [PubMed] [Google Scholar]
- 134).van den Berghe , H. , Cassiman , J. J. , David , G. , Fryns , J. P. , Michaux , J. L. and Sokal , G.Distinct haematological disorder with deletion of long arm of No. 5 chromosome . Nature , 251 , 437 – 438 ( 1974. ). [DOI] [PubMed] [Google Scholar]
- 135).Bennett , J. M. , Catovsky , D. , Daniel , M. T. , Flandrin , G. , Galton , D. A. G. , Gralnick , H. R. and Sultan , C.Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French‐American‐British cooperative group . Ann. Intern. Med. , 103 , 620 – 625 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 136).von den Berghe , H. , David , G. , Michaux , J. L. , Sokal , G. and Verwilghen , R.5q‐acute myelogeneous leukemia . Blood , 48 , 624 – 626 ( 1976. ). [PubMed] [Google Scholar]
- 137).Rowley , J. D.5q‐acute myleogeneous leukemia . Blood , 48 , 626 ( 1976. ). 822901 [Google Scholar]
- 138).Bloomfield , C. O. , Goldman , A. , Hassfeld , D. and de la Chapelle , A.Fourth International Workshop of Chromosomes in Leukemia. 1982: Clinical significance of chromosomal abnormalities in acute non‐lymphocytic leukemia . Cancer Genet. Cytogenet. , 11 , 332 – 350 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 139).Le Beau , M. M. , Epstein , N. D. , O'Brien , S. J. , Nienhuis , A. W. , Yang , Y‐C. , Clark , S. C. and Rowley , J. D.The interleukin 3 gene is located on human chromosome 5 and is deleted in myeloid leukemias with a deletion of 5q . Proc. Natl. Acad. Sci. USA , 84 , 5913 – 5917 ( 1987. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 140).Pettenati , M. J. , Le Beau , M. M. , Lemons , R. S. , Shima , E. A. , Kawasaki , E. S. , Larson , R. A. , Sherr , C. J. , Diaz , M. O. and Rowley , J. D.Assignment of CSF‐1 to 5q33. 1: evidence for clustering of genes regulating hematopoiesis and for their involvement in the deletion of the long arm of chromosome 5 in myeloid disorders . Proc. Natl. Acad. Sci. USA , 84 , 2970 – 2974 ( 1987. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 141).Le Beau , M. M. , Westbrook , C. A. , Diaz , M. O. , Larson , R. A. , Rowley , J. D. , Gasson , J. C. , Golde , D. W. and Sherr , C. J.Evidence for the involvement of GM‐CSF and FMS in the deletion (5q) in myeloid disorders . Science , 231 , 984 – 987 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 142).Kobilka , B. K. , Dixon , R. A. F. , Frielle , T. , Dohlman , H. G. , Bolanowski , M. A. , Sigal , J. S. , Yang‐Feng , T. L. , Francke , U. , Caron , M. G. and Lefkowitz , R. J.cDNA for the human β2‐adrenergic receptor: a protein with multiple membrane‐spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet‐derived growth factor . Proc. Natl. Acad. Sci. USA , 84 , 46 – 50 ( 1987. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 143).Weinberger , C. , Evans , R. , Rosenfeld , M. G. , Hullenberg , S. M. , Skarecky , D. and Wasmuth , J. J.Assignment of the human gene encoding the glucocorticoid receptor to the 911–923 region of chromosome 5 . Cytogenet. Cell Genet. , 40 , 776 ( 1985. ). [Google Scholar]
- 144).Friend , S. H. , Bernards , R. , Rogelj , S. , Weinberg , R. A. , Rapaport , J. M. , Albert , D. M. and Dryja , T. P.A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma . Nature , 323 , 643 – 646 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 145).Adkins , B. , Leutz , A. and Graf , T.Autocrine growth induced by src‐related oncogenes in transformed chicken myeloid cells . Cell , 39 , 439 – 445 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 146).Cook , W. D. , Metcalf , D. , Nicola , N. A. , Burgess , A. W. and Walker , F.Malignant transformation of a growth factor‐dependent myeloid cell line by Abelson virus without evidence of an autocrine mechanism . Cell , 41 , 677 – 683 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 147).Pierce , J. H. , Di Fiore , P. P. , Aaronson , S. A. , Potter , M. , Pumphrey , J. , Scott , A. and Ihle , J. N.Neoplastic transformation of mast cells by Abelson‐MuLV: abrogation of IL‐3 dependence by a nonautocrine mechanism . Cell , 41 , 685 – 693 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 148).Cook , W. D. , de Fazekas St.Groth , B. , Miller , J. F. A. P. , MacDonald , H. R. and Gabathuler , R.Abelson virus transformation of an interieukin 2‐dependent antigen‐specific T‐cell line . Mol. Cell. Biol. , 7 , 2631 – 2635 ( 1987. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 149).Rapp , U. R. , Cleveland , J. L. , Brightman , K. , Scott , A. and Ihle , J. N.Abrogation of IL‐3 and IL‐2 dependence by recornbinant murine retroviruses expressing v‐myc oncogenes . Nature , 317 , 434 – 438 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 150).Overell , R. W. , Watson , J. D. , Gallis , B. , Weisser , K. E. , Cosman , D. and Widmer , M. B.Nature and specificity of lymphokine independence induced by a selectable retroviral vector expressing v‐src . Mol. Cell. Biol. , 7 , 3394 – 3401 ( 1987. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 151).Palacios , R. , Kiefer , M. , Brockhaus , M. , Karjalainen , K. , Dembic , Z. , Kisielow , P. and von Boehmer , H.Molecular, cellular, and functional properties of bone marrow T lymphocyte progenitor clones . J. Exp. Med. , 166 , 12 – 32 ( 1987. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 152).Pierce , J. H. , Ruggiero , M. , Fleming , T. P. , Di Fiore , P. P. , Greenberger , J. S. , Varticovski , L. , Schlessinger , J. , Rovera , G. and Aaronson , S. A.Signal transduction through the EGF receptor transfected in IL‐3‐dependent hematopoietic cells . Science , 239 , 628 – 631 ( 1988. ). [DOI] [PubMed] [Google Scholar]
- 153).Berridge , M. J. and Irvine , R. F.Inositol triphosphate, a novel second messenger in cellular signal transduction . Nature , 312 , 315 – 321 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 154).Berridge , M. J. , Heslop , J. P. , Irvine , R. F. and Brown , K. D.Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet‐derived growth factor . Biochem. J. , 222 , 195 – 201 ( 1984. ). [DOI] [PMC free article] [PubMed] [Google Scholar]
- 155).Matuoka , K. , Fukami , K. , Nakanishi , O. , Kawai , S. and Takenawa , T.Mitogenesis in response to PDGF and bombesin abolished by microinjection of antibody to PIP2 , Science , 239 , 640 – 643 ( 1988. ). [DOI] [PubMed] [Google Scholar]
- 156).Cockcroft , S. and Gomperts , B. D.Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase . Nature , 314 , 534 – 536 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 157).Varmus , H. E.The molecular genetics of cellular oncogenes . Ann. Rev. Genet. , 18 , 553 – 612 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 158).Hurley , J. B. , Simon , M. I. , Teplow , D. B. , Robishaw , J. D. and Gilman , A. G.Homologies between signal transducing G proteins and ras gene products . Science , 226 , 860 – 862 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 159).Korn , L. J. , Siebel , C. W. , McCormick , F. and Roth , R. A.Ras p21 as a potential mediator of insulin action in Xenopus oocytes . Science , 236 , 840 – 843 ( 1987. ). [DOI] [PubMed] [Google Scholar]
- 160).Kamata , T. and Feramisco , J. R.Epidermal growth factor stimulates guanine nucleotide binding activity and phosphorylation of ras oncogene proteins . Nature , 310 , 147 – 150 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 161).Wakelam , M. J. O. , Davies , S. A. , Houslay , M. D. , Mckay , I. , Marshall , C. J. and Hall , A.Normal p21N‐ras couples bombesin and other growth factor receptors to inositol phosphate production . Nature , 323 , 173 – 176 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 162).Marshall , C. J.Oncogenes and growth control 1987 . Cell , 49 , 723 – 725 ( 1987. ). [Google Scholar]
- 163).Bar‐Sagi , D. and Feramisco , J. R.Induction of membrane ruffling and fluid‐phase pinocytosis in quiescent fibroblasts by ras proteins . Science , 233 , 1061 – 1068 ( 1986. ). [DOI] [PubMed] [Google Scholar]
- 164).Taniguchi , T.Regulation of cytokine gene expression . Ann. Rev. Immunol. , 6 , 439 – 464 ( 1988. ). [DOI] [PubMed] [Google Scholar]
- 165).Bohrmann , D. , Bos , T. J. , Admon , A. , Nishimura , T. , Vogt , P. K. and Tjian , R.Human proto‐oncogene c‐jun encodes a DNA binding protein with structural and functional properties of transcription factor AP‐1 . Science , 238 , 1386 – 1392 ( 1987. ). [DOI] [PubMed] [Google Scholar]