Abstract
Administration of formaldehyde at doses of 11 to 110 rag/kg body weight by gastric intubation to male F344 rats induced up to 100‐fold increase in ornithine decarboxylase activity with a maximum after 16 hr and up to 49‐fold increase in DNA synthesis with a maximum after 16 hr in the pyloric mucosa of the stomach. These results suggest that formaldehyde has tumor‐promoting activity in carcinogenesis in the glandular stomach.
Keywords: Formaldehyde, Ornithine decarboxylase, DNA synthesis, Rat glandular stomach
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