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Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1988 Dec;79(12):1264–1268. doi: 10.1111/j.1349-7006.1988.tb01554.x

PRODUCTION OF PARATHYROID HORMONE‐RELATED PROTEIN IN ADULT T‐CELL LEUKEMIA CELLS

Satoshi Honda 1, Ken Yamaguchi 1, Yoshio Miyake 1, Nakanobu Hayashi 1, Naoto Adachi 1, Ken‐ichiro Kinoshita 2, Osamu Ikehara 3, Satoshi Kimura 4, Tomohiro Kinoshita 5, Kunitada Shimotohno 1, Masanori Shimoyama 6, Kaoru Abe 6
PMCID: PMC5917667  PMID: 3148595

Abstract

Human parathyroid hormone‐related protein (PTHrP) mRNA was detected in peripheral leukemic cells obtained from adult T‐cell leukemia (ATL) patients as well as in cultured human T‐cell leukemia virus type I (HTLV‐D‐infected T‐cell lines. In contrast, PTHrP mRNA was not detected in other types of leukemic cells. Using radioimmunoassay, immunoreactive PTHrP was also detected in the spent media of HTLV‐I‐infected T‐cell lines. These results suggest that PTHrP plays an important role in developing the hyperealcemia frequently observed in ATL patients.

Keywords: Parathyroid hormone‐related protein, Hypercalcemia, Adult T‐cell leukemia, Human T‐cell leukemia virus, Paraneoplastic syndrome

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