Figure 1.

Stronger connectivity between hand-selective areas in the visual and sensorimotor systems relates to greater prosthesis usage. (A) Individualized regions of interest in an example participant. Hand-selective voxels were identified in lateral occipitotemporal cortex bilaterally by contrasting responses to hand versus object images (green) or in SI/M1 unilaterally by contrasting intact-hand (or dominant hand in controls) versus feet movements (white). The putative sensorimotor missing-hand area was estimated (hatched white) by mirror projecting the intact hand region of interest across hemispheres. CS = central sulcus; R/L = right/left hemispheres; STS = superior temporal sulcus. (B) Visuo-motor functional connectivity (between bilateral lateral occipitotemporal cortex and missing-hand SI/M1): correlations with prosthesis usage in one-handers. Visuomotor connectivity with the intact hand sensorimotor region of interest was regressed out of the missing hand visuo-motor measure. Scatter diagram is fitted with regression line and associated 95% confidence intervals; s.u. = standardized units. (C and D) Correlations for visuomotor connectivity with prosthesis usage (C) and observance (D) in one-handers and controls, respectively. Permutation tests of the null distributions (black) show that the correlation between visuo-motor connectivity and prosthesis usage (red) is significantly greater in one-handers than chance, but not in controls.