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Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1989 Jun;80(6):531–536. doi: 10.1111/j.1349-7006.1989.tb01672.x

Expression of Cytokine mRNA in Leukemic Cells from Adult T Cell Leukemia Patients

Taiichi Kodaka 1, Takashi Uchiyama 1, Hiroshi Umadome 1, Haruto Uchino 1
PMCID: PMC5917791  PMID: 2503474

Abstract

HTLV‐I infection of peripheral mature T cells appears to induce the expression of cellular genes including those of some cytokines and their receptors. We examined the expression of interleukin‐lα (IL‐lα), IL‐lβ, IL‐2, IL‐3, IL‐4 and granulocyte/macrophage colony‐stimulating factor (GM‐CSF) at the mRNA level in fresh leukemic cells from 20 adult T cell leukemia patients to see whether there is any association between cytokine expression and MTLV‐I expression and between their expression and clinical manifestations such as hypercalcemia or neutrophilia. IL‐lα, IL‐Iβ and IL‐3 expression was observed in 3, 7 and 1 of 20 cases examined, respectively. However, there seemed to be no association between IL‐1 expression and clinical manifestations. IL‐2, IL‐4 and GM‐CSF mRNA expression was not detected. HTLV‐I viral RNA expression was detected only in one case in which IL‐3 mRNA was expressed in both peripheral blood and lymph node cells and a relatively high proportion of leukemic cells expressed IL‐2 receptor (p55, Tac). Thus, in the present study we could not find any correlation between cytokine expression and HTLV‐I expression in peripheral blood fresh leukemic cells except in one unusual case.

Keywords: Cytokine expression, Adult T cell leukemia, Human T cell leukemia virus type I

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