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Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1989 Jun;80(6):506–508. doi: 10.1111/j.1349-7006.1989.tb01667.x

High Risk of Mother‐to‐Child Transmission of HTLV‐I in p40tax Antibody‐positive Mothers

Takashi Sawada 1,✉, Junichi Tohmatsu 1, Takashi Obara 1, Atsushi Koide 1, Shimeru Kamihira 2, Michito Ichimaru 2, Seizaburo Kashiwagi 3, Wataru Kajiyama 3, Nobuyuki Matsumura 4, Kenichiro Kinoshita 4, Michitami Yano 4, Kazunari Yamaguchi 5, Tetsuyuki Kiyokawa 5, Kiyoshi Takatsuki 5, Hirokuni Taguchi 6, Isao Miyoshi 6
PMCID: PMC5917792  PMID: 2503470

Abstract

A new enzyme‐linked immunosorbent assay (ELISA) for detecting the antibody to a human T‐lymphotropic virus type I (HTLV‐I) tax gene product, p40tax, has been developed. By this ELISA method, we have investigated the relationship between the presence of p40tax antibody in HTLV‐I‐infected mothers and the virus transmission rate from mothers to their children. The rate of mother‐to‐child transmission of HTLV‐I was higher in P40tax antibody‐positive mothers than in antibody‐negative ones. Thus, the presence of P40tax antibody may indicate an increased risk of vertical transmission of HTLV‐I.

Keywords: HTLV‐I, p40tax antibody, Mother‐to‐child transmission

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