Abstract
Epstein‐Barr virus (EBV) is known to be associated with two malignant diseases, nasopharyngeal carcinoma (NPC) and endemic Burkitt's lymphoma. In this study, the genomes of EBV in biopsy specimens from 4 NFC patients in Japan were analyzed using Southern blot hybridization. The NPC tissues of all examined cases contained rearranged EBV genomes whose BamHI H fragments were larger than those of prototype EBV genomes. One of them had a BamHI fragment containing contiguous sequences of BamHI Y and H. A single‐sized EBV DNA terminus was observed in these NPC tissues, implying the evolution of the carcinoma from a single EBV‐infected cell.
Keywords: Epstein‐Barr virus, Nasopharyngeal carcinoma, Southern blot hybridization, EBV nuclear antigen
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