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Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1989 Dec;80(12):1161–1164. doi: 10.1111/j.1349-7006.1989.tb01648.x

In vivo Antitumor Mechanism of Natural Human Tumor Necrosis Factor Involving a T Cell‐mediated Immunological Route

Tetsuya Asami 1, Meroni Imai 2, Yasuo Tanaka 2, Yoshitaka Hosaka 2, Kazuharu Kato 1, Norio Nakamura 1, Yoshifumi Horisawa 3, Yoshikazu Ashida 1, Toshinori Kanamori 1, Masahiro Nobuhara 1,3, Masashi Kurimoto 4
PMCID: PMC5917930  PMID: 2516844

Abstract

We have investigated the in vivo antitumor mechanism of natural human tumor necrosis factor (n‐TNF) isolated from a culture of human leukemic B cell line (BALL‐1), especially its action as an immunomodulator, and found that the in vivo antitumor effect of n‐TNF on Meth A sarcoma implanted in BALB/c mice pretreated with monoclonal antibody against T cell‐specific surface antigen (Thy‐1) was significantly diminished. Furthermore, when BALB/c mice were treated with T cell subset‐specific monoclonal antibodies, anti‐L3T4 or anti‐Lyt‐2.2, the antitumor effect of n‐TNF on Meth A sarcoma was significantly reduced. Therefore, it was suggested that the in vivo antitumor mechanism of n‐TNF might involve a T cell‐mediated immunological route.

Keywords: Tumor necrosis factor, In vivo antitumor mechanism, T cell subset, Monoclonal antibody

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