ABSTRACT
The carcinogenic potential of 2‐amino‐3‐methylimidazo[4,5f]quinoline (IQ) was evaluated in cynomolgus monkeys. Monkeys received IQ, beginning at the age of one year, at doses of 10 or 20 mg/kg by gavage. Thus far, IQ has induced hepatocellular carcinoma in three monkeys with a latent period of 27 to 37 months. Metastases to the lung occurred in two of the three monkeys. Microscopically, the hepatocellular carcinoma in all three cases demonstrated a trabecular pattern. These data demonstrate that IQ is a potent carcinogen in nonhuman primates and support the idea that it is a potential carcinogen for humans.
Keywords: Hepatocellular carcinoma, Heterocyclic amines, Nonhuman primates
Full Text
The Full Text of this article is available as a PDF (544.2 KB).
REFERENCES
- 1. ) Sugimura , T.Carcinogenicity of mutagenic heterocyclic amines formed during the cooking process . Mutat. Res. , 150 , 33 – 41 ( 1985. ). [DOI] [PubMed] [Google Scholar]
- 2. ) Ohgaki , H. , Kusama , K. , Matsukura , N. , Morino , K. , Hasegawa , H. , Sato , S. , Takayama , S. and Sugimura , T.Carcinogenicity in mice of a mutagenic compound, 2‐amino‐3‐methylimidazo[4,5f]quinoline, from broiled sardine, cooked beef and beef extract . Carcinogenesis , 5 , 921 – 924 ( 1984. ). [DOI] [PubMed] [Google Scholar]
- 3. ) Takayama , S. , Nakatsuru , Y. , Masuda , M. , Ohgaki , H. , Sato , S. and Sugimura , T.Demonstration of carcinogenicity in F344 rats of 2‐amino‐3‐methylimidazo[4,5f]quinoline from broiled sardine, fried beef and beef extract . Gann , 75 , 467 – 470 ( 1984. ). [PubMed] [Google Scholar]
- 4. ) Adamson , R. H. , Krolikowski , F. J. , Correa , P. , Sieber , S. M. and Dalgard , D. W.Carcinogenicity of 1‐methylnitrosourea in nonhuman primates . J. Natl. Cancer Inst. , 59 , 415 – 422 ( 1977. ). [Google Scholar]
- 5. ) Adamson , R. H. and Sieber , S. M.The use of nonhuman primates for chemical carcinogenesis studies . In “ Regulatory Aspects of Carcinogenesis and Food Additives: The Delaney Clause ,” ed. Coulston F. , pp. 275 – 296 ( 1979. ). Academic Press; , New York . [Google Scholar]
- 6. ) Adamson , R. H. and Sieber , S. M.Studies on the oncogenicity of procarbazine and other compounds in nonhuman primates . In “ Malignant Lymphomas: Etiology, Immunology, Pathology, Treatment ,” ed. Rosenberg S. A. and Kaplan H. S. , pp. 239 – 257 ( 1982. ). Academic Press; , New York . [Google Scholar]
- 7. ) Adamson , R. H. and Sieber , S. M.Chemical carcinogenesis studies in nonhuman primates . In “ Organ and Species Specificity in Chemical Carcinogenesis ,” ed. Langenbach R. , Nesnow S. and Rice J. , pp. 129 – 156 ( 1983. ). Plenum Publishing Corp. , New York . [DOI] [PubMed] [Google Scholar]