Abstract
The influence upon nickel subsulfide (α‐Ni3S2; Ni‐SS)‐induced carcinogenesis in the soft tissue of bone fracture at the site of Ni‐SS exposure was studied using female Fischer rats. During the one year of the experiment, the group subjected to bone fracture exhibited the shortest tumor induction time and survival time, and a significantly higher metastatic rate. The present study may suggest a model for the metastasis of human soft tissue tumors.
Keywords: Experimental carcinogenesis, Nickel subsulfide, Bone fracture, Sarcoma, Soft tissue tumor
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