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Japanese Journal of Cancer Research : Gann logoLink to Japanese Journal of Cancer Research : Gann
. 1990 Mar;81(3):213–215. doi: 10.1111/j.1349-7006.1990.tb02551.x

Significant Increase of 8‐Hydroxydeoxyguanosine in Liver DNA of Rats Following Short‐term Exposure to the Peroxisome Proliferators Di(2‐ethylhexyl)phthalate and Di(2‐ethylhexyl)adipate

Atsuya Takagi 1, Kimie Sai 1, Takashi Umemura 1, Ryuichi Hasegawa 1, Yuji Kurokawa 1
PMCID: PMC5918022  PMID: 2112523

Abstract

8‐Hydroxydeoxyguanosine (8‐OH‐dG) levels were examined in liver and kidney DNA after di(2‐ethylhexyl)phthalate (DEHP), di(2‐ethylhexyl)adipate (DEHA) and phthalic anhydride administration to male 6‐week‐old F‐344 rats in the diet at concentrations of 1.2, 2.5 and 1.5%, respectively. Significant increases in 8‐OH‐dG levels were observed only in the liver (target organ of DEHP and DEHA carcinogenesis) DNA after 1 and 2 weeks of treatment with DEHP and DEHA, respectively. The results suggest the involvement of oxidative DNA damage in hepatocarcinogenesis by peroxisome proliferators.

Keywords: 8‐Hydroxydeoxyguanosine, Peroxisome proliferator, Di(2‐ethylhexyl)phthalate, Di(2‐ethylhexyl)adipate, DNA damage

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