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. 1990 Apr;81(4):340–344. doi: 10.1111/j.1349-7006.1990.tb02573.x

Oligoclonal Immunoglobulin Gene Rearrangements in Philadelphia Chromosome‐positive Common Acute Lymphoblastic Leukemia

Takeshi Ikeda 1, Kenkichi Kita 1,✉, Keiki Kawakami 1, Toshiyuki Ohno 1, Shigeki Seki 2, Kaori Nasu 3, Takanori Ueda 4, Tasuku Honjo 5, Shigeru Shirakawa 1
PMCID: PMC5918038  PMID: 2114388

Abstract

The occurrence of more than two rearranged bands of immunoglobulin heavy chain (IgH) genes in B precursor acute lymphoblastic leukemia (ALL) has recently been documented. To elucidate the nature of such leukemias, we studied 30 patients with common ALL, including 6 patients with Philadelphia chromosome (Ph1)‐positive ALL, by immunophenotyping and genotyping. In 10 of the 30, Southern blotting showed oligoclonal patterns of IgH gene arrangements, which were frequently detected in Ph1‐positive ALL. In one patient of the 10, three rearranged bands of Ig k chain genes were detected. Ph1 abnormality and co‐expression of myeloid associated antigens were found in 5 and 5 of the 10, respectively. Detection of multiple fragments of IgH genes would be suggestive of multipotent progenitor origin of these ALL.

Keywords: Immunoglobulin gene, Ph1‐positive common acute lymphoblastic leukemia

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